Basic Information

Symbol
circPRKCI
RNA Class
circRNA
Alias
Protein Kinase C Iota DXS1179E PKCI Atypical Protein Kinase C-Lambda/Iota Protein Kinase C Iota Type PRKC-Lambda/Iota APKC-Lambda/Iota EC 2.7.11.13 NPKC-Iota Protein Kinase C, Iota EC 2.7.11
Location (GRCh37)
3:169953018-170046704 UCSC Genome Browser
Location (GRCh38)
3:170235230-170328916
UCSC Genome Browser Search in Marker Scope
Host gene
PRKCI
Host category
mRNA
Forensic tag(s)
Other applications
External database
circbank

Transcripts

ID Type Location (GRCh37) Location (GRCh38) Length GC content
hsa_PRKCI_0002600 Intron-Exon-Intron chr3:169977316-169981217 chr3:170259528-170263429 582 nt 0.4278
hsa_PRKCI_0002700 Intron-Exon-Intron chr3:169977316-169991128 chr3:170259528-170273340 864 nt 0.4502
hsa_PRKCI_0003000 Intron-Exon-Intron chr3:169977757-169978383 chr3:170259969-170260595 627 nt 0.3700
hsa_PRKCI_0003100 Exon-Exon chr3:169977757-169985788 chr3:170259969-170268000 227 nt 0.4670
hsa_PRKCI_0003600 Exon-Exon chr3:169977757-169988349 chr3:170259969-170270561 141 nt 0.4823
hsa_PRKCI_0003200 Exon-Exon chr3:169977757-169991128 chr3:170259969-170273340 423 nt 0.4775
hsa_PRKCI_0003700 Exon-Exon chr3:169977757-169993075 chr3:170259969-170275287 90 nt 0.4000
hsa_PRKCI_0003300 Exon-Exon chr3:169977757-169999756 chr3:170259969-170281968 844 nt 0.4336
hsa_PRKCI_0003800 Intron-Exon-Intron chr3:169977757-170003674 chr3:170259969-170285886 90 nt 0.4000
hsa_PRKCI_0003400 Exon-Exon chr3:169977757-170011296 chr3:170259969-170293508 1194 nt 0.4288
Showing 51 to 60 of 114 entries
Forensic Context

A study in humans demonstrated that circPRKCI is significantly upregulated in lung adenocarcinoma and squamous cell carcinoma tissues, where it promotes cancer cell proliferation, migration, and invasion by acting as a sponge for miR-545 and miR-589 to elevate E2F7 expression [Zhang et al. DOI:10.1038/s41418-022-00948-7]. A review of human studies indicates that the circPRKCI is upregulated in oesophageal squamous cell carcinoma tissues and its expression is associated with tumor differentiation and stage, while its downregulation suppresses cancer cell proliferation and migration [Lee et al. DOI:10.1016/j.biopha.2018.12.052].