Basic Information

Symbol
circPRKCI
RNA Class
circRNA
Alias
Protein Kinase C Iota DXS1179E PKCI Atypical Protein Kinase C-Lambda/Iota Protein Kinase C Iota Type PRKC-Lambda/Iota APKC-Lambda/Iota EC 2.7.11.13 NPKC-Iota Protein Kinase C, Iota EC 2.7.11
Location (GRCh37)
3:169953018-170046704 UCSC Genome Browser
Location (GRCh38)
3:170235230-170328916
UCSC Genome Browser Search in Marker Scope
Host gene
PRKCI
Host category
mRNA
Forensic tag(s)
Other applications
External database
circbank

Transcripts

ID Type Location (GRCh37) Location (GRCh38) Length GC content
hsa_PRKCI_0003900 Exon-Exon chr3:169977757-170015181 chr3:170259969-170297393 90 nt 0.4000
hsa_PRKCI_0003500 Exon-Exon chr3:169977757-170016898 chr3:170259969-170299110 1480 nt 0.4243
hsa_PRKCI_0004100 Exon-Exon chr3:169981167-170002384 chr3:170263379-170284596 890 nt 0.4270
hsa_PRKCI_0004200 Exon-Exon chr3:169981167-170015181 chr3:170263379-170297393 1274 nt 0.4270
hsa_PRKCI_0004300 Exon-Exon chr3:169981185-169998083 chr3:170263397-170280295 33 nt 0.5152
hsa_PRKCI_0004400 Intron-Exon-Intron chr3:169982303-169987486 chr3:170264515-170269698 250 nt 0.3760
hsa_PRKCI_0004500 Intron-Intron chr3:169982345-169982579 chr3:170264557-170264791 235 nt 0.4085
hsa_PRKCI_0005200 Exon-Exon chr3:169985703-169988349 chr3:170267915-170270561 141 nt 0.4823
hsa_PRKCI_0004700 Exon-Exon chr3:169985703-169991128 chr3:170267915-170273340 282 nt 0.4965
hsa_PRKCI_0004800 Exon-Exon chr3:169985703-169993075 chr3:170267915-170275287 341 nt 0.4692
Showing 61 to 70 of 114 entries
Forensic Context

A study in humans demonstrated that circPRKCI is significantly upregulated in lung adenocarcinoma and squamous cell carcinoma tissues, where it promotes cancer cell proliferation, migration, and invasion by acting as a sponge for miR-545 and miR-589 to elevate E2F7 expression [Zhang et al. DOI:10.1038/s41418-022-00948-7]. A review of human studies indicates that the circPRKCI is upregulated in oesophageal squamous cell carcinoma tissues and its expression is associated with tumor differentiation and stage, while its downregulation suppresses cancer cell proliferation and migration [Lee et al. DOI:10.1016/j.biopha.2018.12.052].