Basic Information

Symbol
circPRKCI
RNA Class
circRNA
Alias
Protein Kinase C Iota DXS1179E PKCI Atypical Protein Kinase C-Lambda/Iota Protein Kinase C Iota Type PRKC-Lambda/Iota APKC-Lambda/Iota EC 2.7.11.13 NPKC-Iota Protein Kinase C, Iota EC 2.7.11
Location (GRCh37)
3:169953018-170046704 UCSC Genome Browser
Location (GRCh38)
3:170235230-170328916
UCSC Genome Browser Search in Marker Scope
Host gene
PRKCI
Host category
mRNA
Forensic tag(s)
Other applications
External database
circbank

Transcripts

ID Type Location (GRCh37) Location (GRCh38) Length GC content
hsa_PRKCI_0005300 Exon-Exon chr3:169985703-169999051 chr3:170267915-170281263 86 nt 0.5116
hsa_PRKCI_0004900 Exon-Exon chr3:169985703-170002384 chr3:170267915-170284596 839 nt 0.4219
hsa_PRKCI_0005000 Exon-Exon chr3:169985703-170011296 chr3:170267915-170293508 1053 nt 0.4274
hsa_PRKCI_0005100 Exon-Exon chr3:169985703-170016898 chr3:170267915-170299110 1339 nt 0.4227
hsa_PRKCI_0005400 Intron-Exon-Intron chr3:169986176-169989716 chr3:170268388-170271928 250 nt 0.4000
hsa_PRKCI_0005800 Exon-Exon chr3:169988209-169993075 chr3:170270421-170275287 141 nt 0.4823
hsa_PRKCI_0005900 Exon-Exon chr3:169988209-169998191 chr3:170270421-170280403 177 nt 0.3842
hsa_PRKCI_0005600 Exon-Exon chr3:169988209-170002384 chr3:170270421-170284596 753 nt 0.4117
hsa_PRKCI_0005500 Intron-Exon-Intron chr3:169988209-170003674 chr3:170270421-170285886 2043 nt 0.3906
hsa_PRKCI_0006000 Exon-Exon chr3:169988209-170011296 chr3:170270421-170293508 141 nt 0.4823
Showing 71 to 80 of 114 entries
Forensic Context

A study in humans demonstrated that circPRKCI is significantly upregulated in lung adenocarcinoma and squamous cell carcinoma tissues, where it promotes cancer cell proliferation, migration, and invasion by acting as a sponge for miR-545 and miR-589 to elevate E2F7 expression [Zhang et al. DOI:10.1038/s41418-022-00948-7]. A review of human studies indicates that the circPRKCI is upregulated in oesophageal squamous cell carcinoma tissues and its expression is associated with tumor differentiation and stage, while its downregulation suppresses cancer cell proliferation and migration [Lee et al. DOI:10.1016/j.biopha.2018.12.052].