Basic Information

Symbol
circPRKCI
RNA Class
circRNA
Alias
Protein Kinase C Iota DXS1179E PKCI Atypical Protein Kinase C-Lambda/Iota Protein Kinase C Iota Type PRKC-Lambda/Iota APKC-Lambda/Iota EC 2.7.11.13 NPKC-Iota Protein Kinase C, Iota EC 2.7.11
Location (GRCh37)
3:169953018-170046704 UCSC Genome Browser
Location (GRCh38)
3:170235230-170328916
UCSC Genome Browser Search in Marker Scope
Host gene
PRKCI
Host category
mRNA
Forensic tag(s)
Other applications
External database
circbank

Transcripts

ID Type Location (GRCh37) Location (GRCh38) Length GC content
hsa_PRKCI_0006100 Exon-Exon chr3:169988209-170015181 chr3:170270421-170297393 90 nt 0.4556
hsa_PRKCI_0005700 Exon-Exon chr3:169988209-170016898 chr3:170270421-170299110 1253 nt 0.4166
hsa_PRKCI_0006600 Exon-Exon chr3:169991074-170002384 chr3:170273286-170284596 612 nt 0.3954
hsa_PRKCI_0006700 Exon-Exon chr3:169991074-170013778 chr3:170273286-170295990 906 nt 0.4029
hsa_PRKCI_0006800 Intron-Exon-Intron chr3:169991490-169996942 chr3:170273702-170279154 250 nt 0.4560
hsa_PRKCI_0007200 Exon-Exon chr3:169998015-169999756 chr3:170280227-170281968 177 nt 0.3842
hsa_PRKCI_0007300 Exon-Exon chr3:169998015-170002384 chr3:170280227-170284596 177 nt 0.3842
hsa_PRKCI_0006900 Intron-Exon-Intron chr3:169998015-170003674 chr3:170280227-170285886 1788 nt 0.3814
hsa_PRKCI_0007400 Exon-Exon chr3:169998015-170009729 chr3:170280227-170291941 177 nt 0.3842
hsa_PRKCI_0007000 Exon-Exon chr3:169998015-170011296 chr3:170280227-170293508 712 nt 0.4073
Showing 81 to 90 of 114 entries
Forensic Context

A study in humans demonstrated that circPRKCI is significantly upregulated in lung adenocarcinoma and squamous cell carcinoma tissues, where it promotes cancer cell proliferation, migration, and invasion by acting as a sponge for miR-545 and miR-589 to elevate E2F7 expression [Zhang et al. DOI:10.1038/s41418-022-00948-7]. A review of human studies indicates that the circPRKCI is upregulated in oesophageal squamous cell carcinoma tissues and its expression is associated with tumor differentiation and stage, while its downregulation suppresses cancer cell proliferation and migration [Lee et al. DOI:10.1016/j.biopha.2018.12.052].