Basic Information
Symbol
circPTK2
RNA Class
circRNA
Alias
Protein Tyrosine Kinase 2
PPP1R71
FAK1
FAK
FADK
Protein Phosphatase 1 Regulatory Subunit 71
Focal Adhesion Kinase-Related Nonkinase
PTK2 Protein Tyrosine Kinase 2
Focal Adhesion Kinase 1
EC 2.7.10.2
Pp125FAK
P125FAK
FADK 1
FRNK
Protein Phosphatase 1, Regulatory Subunit 71
FAK-Related Non-Kinase Polypeptide
Protein-Tyrosine Kinase 2
EC 2.7.10
Location (GRCh37)
8:141668481-142005154
UCSC Genome Browser
Location (GRCh38)
8:140658382-140995055
Host gene
PTK2
Host category
mRNA
Forensic tag(s)
Sudden death from CNS diseases
External database
Transcripts
| ID | Type | Location (GRCh37) | Location (GRCh38) | Length | GC content |
|---|---|---|---|---|---|
| hsa_PTK2_0000100 | Exon-Exon | chr8:141668481-141828453 | chr8:140658382-140818354 | 250 nt | 0.3160 |
| hsa_PTK2_0000200 | Exon-Exon | chr8:141668481-141935848 | chr8:140658382-140925749 | 250 nt | 0.3200 |
| hsa_PTK2_0000600 | Exon-Exon | chr8:141675016-141684503 | chr8:140664917-140674404 | 353 nt | 0.5836 |
| hsa_PTK2_0001000 | Exon-Exon | chr8:141675016-141716304 | chr8:140664917-140706205 | 843 nt | 0.5302 |
| hsa_PTK2_0001200 | Exon-Exon | chr8:141675016-141803483 | chr8:140664917-140793384 | 1892 nt | 0.4820 |
| hsa_PTK2_0001300 | Exon-Exon | chr8:141675016-141829119 | chr8:140664917-140819020 | 2337 nt | 0.4737 |
| hsa_PTK2_0001400 | Exon-Exon | chr8:141675016-141856777 | chr8:140664917-140846678 | 2535 nt | 0.4671 |
| hsa_PTK2_0001700 | Exon-Exon | chr8:141678368-141684503 | chr8:140668269-140674404 | 272 nt | 0.5809 |
| hsa_PTK2_0001900 | Exon-Exon | chr8:141678368-141716304 | chr8:140668269-140706205 | 762 nt | 0.5236 |
| hsa_PTK2_0002300 | Exon-Exon | chr8:141679826-141856777 | chr8:140669727-140846678 | 2298 nt | 0.4569 |
Showing 1 to 10 of 573 entries
Forensic Context
A study in mice demonstrated that the circPTK2 is induced after oxygen-glucose deprivation and regulates microglia-induced hippocampal neuronal apoptosis via the miR-29b/SOCS-1-JAK2/STAT3-IL-1β axis [Huang et al. DOI:10.3390/cells11091381]. In a separate review, the circPTK2 was similarly noted to be induced after stroke, where it suppresses miR-29b, leading to JAK2/STAT3 activation, IL-1β production, and neuronal apoptosis [Mehta et al. DOI:10.1016/j.pneurobio.2020.101746].