Basic Information

Symbol
circPTK2
RNA Class
circRNA
Alias
Protein Tyrosine Kinase 2 PPP1R71 FAK1 FAK FADK Protein Phosphatase 1 Regulatory Subunit 71 Focal Adhesion Kinase-Related Nonkinase PTK2 Protein Tyrosine Kinase 2 Focal Adhesion Kinase 1 EC 2.7.10.2 Pp125FAK P125FAK FADK 1 FRNK Protein Phosphatase 1, Regulatory Subunit 71 FAK-Related Non-Kinase Polypeptide Protein-Tyrosine Kinase 2 EC 2.7.10
Location (GRCh37)
8:141668481-142005154 UCSC Genome Browser
Location (GRCh38)
8:140658382-140995055
UCSC Genome Browser Search in Marker Scope
Host gene
PTK2
Host category
mRNA
Forensic tag(s)
Sudden death from CNS diseases
External database
circbank

Transcripts

ID Type Location (GRCh37) Location (GRCh38) Length GC content
hsa_PTK2_0036500 Exon-Exon chr8:141828376-141856777 chr8:140818277-140846678 417 nt 0.3957
hsa_PTK2_0036600 Exon-Exon chr8:141828376-141874498 chr8:140818277-140864399 505 nt 0.3802
hsa_PTK2_0036700 Exon-Exon chr8:141828376-141889736 chr8:140818277-140879637 672 nt 0.4182
hsa_PTK2_0036800 Exon-Exon chr8:141828376-141900868 chr8:140818277-140890769 899 nt 0.4238
hsa_PTK2_0036900 Exon-Exon chr8:141828376-141935848 chr8:140818277-140925749 988 nt 0.4322
hsa_PTK2_0038800 Exon-Exon chr8:141828979-141935848 chr8:140818880-140925749 910 nt 0.4286
hsa_PTK2_0039600 Intron-Exon-Intron chr8:141837078-141874498 chr8:140826979-140864399 250 nt 0.3080
hsa_PTK2_0040300 Exon-Exon chr8:141840571-141874498 chr8:140830472-140864399 286 nt 0.3636
hsa_PTK2_0040400 Exon-Exon chr8:141840571-141889736 chr8:140830472-140879637 453 nt 0.4260
hsa_PTK2_0041200 Exon-Exon chr8:141840571-141900868 chr8:140830472-140890769 680 nt 0.4309
Showing 91 to 100 of 573 entries
Forensic Context

A study in mice demonstrated that the circPTK2 is induced after oxygen-glucose deprivation and regulates microglia-induced hippocampal neuronal apoptosis via the miR-29b/SOCS-1-JAK2/STAT3-IL-1β axis [Huang et al. DOI:10.3390/cells11091381]. In a separate review, the circPTK2 was similarly noted to be induced after stroke, where it suppresses miR-29b, leading to JAK2/STAT3 activation, IL-1β production, and neuronal apoptosis [Mehta et al. DOI:10.1016/j.pneurobio.2020.101746].