Basic Information

Symbol
circPTK2
RNA Class
circRNA
Alias
Protein Tyrosine Kinase 2 PPP1R71 FAK1 FAK FADK Protein Phosphatase 1 Regulatory Subunit 71 Focal Adhesion Kinase-Related Nonkinase PTK2 Protein Tyrosine Kinase 2 Focal Adhesion Kinase 1 EC 2.7.10.2 Pp125FAK P125FAK FADK 1 FRNK Protein Phosphatase 1, Regulatory Subunit 71 FAK-Related Non-Kinase Polypeptide Protein-Tyrosine Kinase 2 EC 2.7.10
Location (GRCh37)
8:141668481-142005154 UCSC Genome Browser
Location (GRCh38)
8:140658382-140995055
UCSC Genome Browser Search in Marker Scope
Host gene
PTK2
Host category
mRNA
Forensic tag(s)
Sudden death from CNS diseases
External database
circbank

Transcripts

ID Type Location (GRCh37) Location (GRCh38) Length GC content
hsa_PTK2_0040500 Exon-Exon chr8:141840571-141935848 chr8:140830472-140925749 769 nt 0.4408
hsa_PTK2_0042500 Exon-Exon chr8:141856359-141856777 chr8:140846260-140846678 143 nt 0.4126
hsa_PTK2_0042600 Exon-Exon chr8:141856359-141874498 chr8:140846260-140864399 231 nt 0.3723
hsa_PTK2_0042700 Exon-Exon chr8:141856359-141889736 chr8:140846260-140879637 398 nt 0.4397
hsa_PTK2_0042800 Exon-Exon chr8:141856359-141900868 chr8:140846260-140890769 625 nt 0.4400
hsa_PTK2_0044000 Exon-Exon chr8:141856359-141931231 chr8:140846260-140921132 250 nt 0.3280
hsa_PTK2_0042900 Exon-Exon chr8:141856359-141935848 chr8:140846260-140925749 714 nt 0.4496
hsa_PTK2_0044400 Exon-Exon chr8:141856698-141889736 chr8:140846599-140879637 335 nt 0.4418
hsa_PTK2_0044700 Exon-Exon chr8:141856698-141900868 chr8:140846599-140890769 562 nt 0.4413
hsa_PTK2_0045800 Exon-Exon chr8:141874411-141874498 chr8:140864312-140864399 88 nt 0.3068
Showing 101 to 110 of 573 entries
Forensic Context

A study in mice demonstrated that the circPTK2 is induced after oxygen-glucose deprivation and regulates microglia-induced hippocampal neuronal apoptosis via the miR-29b/SOCS-1-JAK2/STAT3-IL-1β axis [Huang et al. DOI:10.3390/cells11091381]. In a separate review, the circPTK2 was similarly noted to be induced after stroke, where it suppresses miR-29b, leading to JAK2/STAT3 activation, IL-1β production, and neuronal apoptosis [Mehta et al. DOI:10.1016/j.pneurobio.2020.101746].