Basic Information

Symbol
circPTK2
RNA Class
circRNA
Alias
Protein Tyrosine Kinase 2 PPP1R71 FAK1 FAK FADK Protein Phosphatase 1 Regulatory Subunit 71 Focal Adhesion Kinase-Related Nonkinase PTK2 Protein Tyrosine Kinase 2 Focal Adhesion Kinase 1 EC 2.7.10.2 Pp125FAK P125FAK FADK 1 FRNK Protein Phosphatase 1, Regulatory Subunit 71 FAK-Related Non-Kinase Polypeptide Protein-Tyrosine Kinase 2 EC 2.7.10
Location (GRCh37)
8:141668481-142005154 UCSC Genome Browser
Location (GRCh38)
8:140658382-140995055
UCSC Genome Browser Search in Marker Scope
Host gene
PTK2
Host category
mRNA
Forensic tag(s)
Sudden death from CNS diseases
External database
circbank

Transcripts

ID Type Location (GRCh37) Location (GRCh38) Length GC content
hsa_PTK2_0045900 Exon-Exon chr8:141874411-141889736 chr8:140864312-140879637 255 nt 0.4549
hsa_PTK2_0046000 Exon-Exon chr8:141874411-141900868 chr8:140864312-140890769 482 nt 0.4481
hsa_PTK2_0047300 Exon-Exon chr8:141874411-141935848 chr8:140864312-140925749 571 nt 0.4588
hsa_PTK2_0047800 Intron-Intron chr8:141880585-141884629 chr8:140870486-140874530 250 nt 0.2960
hsa_PTK2_0048100 Intron-Exon-Intron chr8:141884562-141900868 chr8:140874463-140890769 250 nt 0.3120
hsa_PTK2_0048400 Exon-Exon chr8:141889570-141900868 chr8:140879471-140890769 394 nt 0.4797
hsa_PTK2_0049300 Exon-Exon chr8:141889570-141935848 chr8:140879471-140925749 483 nt 0.4865
hsa_PTK2_0048500 Exon-Exon chr8:141889570-141994254 chr8:140879471-140984155 472 nt 0.5021
hsa_PTK2_0050500 Exon-Exon chr8:141900642-141900868 chr8:140890543-140890769 227 nt 0.4405
hsa_PTK2_0052100 Exon-Exon chr8:141935760-141935848 chr8:140925661-140925749 89 nt 0.5169
Showing 111 to 120 of 573 entries
Forensic Context

A study in mice demonstrated that the circPTK2 is induced after oxygen-glucose deprivation and regulates microglia-induced hippocampal neuronal apoptosis via the miR-29b/SOCS-1-JAK2/STAT3-IL-1β axis [Huang et al. DOI:10.3390/cells11091381]. In a separate review, the circPTK2 was similarly noted to be induced after stroke, where it suppresses miR-29b, leading to JAK2/STAT3 activation, IL-1β production, and neuronal apoptosis [Mehta et al. DOI:10.1016/j.pneurobio.2020.101746].