Basic Information

Symbol
circPTK2
RNA Class
circRNA
Alias
Protein Tyrosine Kinase 2 PPP1R71 FAK1 FAK FADK Protein Phosphatase 1 Regulatory Subunit 71 Focal Adhesion Kinase-Related Nonkinase PTK2 Protein Tyrosine Kinase 2 Focal Adhesion Kinase 1 EC 2.7.10.2 Pp125FAK P125FAK FADK 1 FRNK Protein Phosphatase 1, Regulatory Subunit 71 FAK-Related Non-Kinase Polypeptide Protein-Tyrosine Kinase 2 EC 2.7.10
Location (GRCh37)
8:141668481-142005154 UCSC Genome Browser
Location (GRCh38)
8:140658382-140995055
UCSC Genome Browser Search in Marker Scope
Host gene
PTK2
Host category
mRNA
Forensic tag(s)
Sudden death from CNS diseases
External database
circbank

Transcripts

ID Type Location (GRCh37) Location (GRCh38) Length GC content
hsa_PTK2_0054000 Intron-Intron chr8:141982991-141983380 chr8:140972892-140973281 390 nt 0.3615
hsa_PTK2_0000400 Intron-Intron chr8:141670140-141670655 chr8:140660041-140660556 516 nt 0.4535
hsa_PTK2_0000300 Intron-Exon-Intron chr8:141670140-141684503 chr8:140660041-140674404 250 nt 0.4280
hsa_chr8_0161700 Intergenic-Intergenic chr8:141672436-141673075 chr8:140662337-140662976 640 nt 0.4125
hsa_chr8_0161800 Intergenic-Intergenic chr8:141673669-141674133 chr8:140663570-140664034 465 nt 0.4172
hsa_PTK2_0000500 Exon-Exon chr8:141675016-141678523 chr8:140664917-140668424 237 nt 0.5654
hsa_PTK2_0000700 Intron-Exon-Intron chr8:141675016-141684810 chr8:140664917-140674711 660 nt 0.5500
hsa_PTK2_0000800 Exon-Exon chr8:141675016-141685598 chr8:140664917-140675499 384 nt 0.5625
hsa_PTK2_0000900 Exon-Exon chr8:141675016-141696793 chr8:140664917-140686694 300 nt 0.5567
hsa_PTK2_0001100 Exon-Exon chr8:141675016-141762415 chr8:140664917-140752316 1653 nt 0.4894
Showing 121 to 130 of 573 entries
Forensic Context

A study in mice demonstrated that the circPTK2 is induced after oxygen-glucose deprivation and regulates microglia-induced hippocampal neuronal apoptosis via the miR-29b/SOCS-1-JAK2/STAT3-IL-1β axis [Huang et al. DOI:10.3390/cells11091381]. In a separate review, the circPTK2 was similarly noted to be induced after stroke, where it suppresses miR-29b, leading to JAK2/STAT3 activation, IL-1β production, and neuronal apoptosis [Mehta et al. DOI:10.1016/j.pneurobio.2020.101746].