Basic Information

Symbol
circPTK2
RNA Class
circRNA
Alias
Protein Tyrosine Kinase 2 PPP1R71 FAK1 FAK FADK Protein Phosphatase 1 Regulatory Subunit 71 Focal Adhesion Kinase-Related Nonkinase PTK2 Protein Tyrosine Kinase 2 Focal Adhesion Kinase 1 EC 2.7.10.2 Pp125FAK P125FAK FADK 1 FRNK Protein Phosphatase 1, Regulatory Subunit 71 FAK-Related Non-Kinase Polypeptide Protein-Tyrosine Kinase 2 EC 2.7.10
Location (GRCh37)
8:141668481-142005154 UCSC Genome Browser
Location (GRCh38)
8:140658382-140995055
UCSC Genome Browser Search in Marker Scope
Host gene
PTK2
Host category
mRNA
Forensic tag(s)
Sudden death from CNS diseases
External database
circbank

Transcripts

ID Type Location (GRCh37) Location (GRCh38) Length GC content
hsa_chr8_0161900 Intergenic-Intergenic chr8:141675082-141678484 chr8:140664983-140668385 117 nt 0.5299
hsa_PTK2_0001500 Intron-Intron chr8:141675349-141675979 chr8:140665250-140665880 631 nt 0.3962
hsa_chr8_0162000 Intergenic-Intergenic chr8:141675451-141678484 chr8:140665352-140668385 250 nt 0.4040
hsa_PTK2_0001600 Exon-Exon chr8:141678368-141678511 chr8:140668269-140668412 144 nt 0.5417
hsa_PTK2_0001800 Exon-Exon chr8:141678368-141685598 chr8:140668269-140675499 303 nt 0.5545
hsa_PTK2_0002000 Exon-Exon chr8:141678368-141727808 chr8:140668269-140717709 199 nt 0.5628
hsa_PTK2_0002100 Exon-Exon chr8:141678368-141756959 chr8:140668269-140746860 101 nt 0.4455
hsa_PTK2_0002200 Exon-Exon chr8:141678368-141762415 chr8:140668269-140752316 148 nt 0.4595
hsa_PTK2_0002700 Intron-Exon-Intron chr8:141684397-141684810 chr8:140674298-140674711 414 nt 0.5386
hsa_PTK2_0002800 Exon-Exon chr8:141684397-141711121 chr8:140674298-140701022 195 nt 0.5026
Showing 131 to 140 of 573 entries
Forensic Context

A study in mice demonstrated that the circPTK2 is induced after oxygen-glucose deprivation and regulates microglia-induced hippocampal neuronal apoptosis via the miR-29b/SOCS-1-JAK2/STAT3-IL-1β axis [Huang et al. DOI:10.3390/cells11091381]. In a separate review, the circPTK2 was similarly noted to be induced after stroke, where it suppresses miR-29b, leading to JAK2/STAT3 activation, IL-1β production, and neuronal apoptosis [Mehta et al. DOI:10.1016/j.pneurobio.2020.101746].