Basic Information
Symbol
circPTK2
RNA Class
circRNA
Alias
Protein Tyrosine Kinase 2
PPP1R71
FAK1
FAK
FADK
Protein Phosphatase 1 Regulatory Subunit 71
Focal Adhesion Kinase-Related Nonkinase
PTK2 Protein Tyrosine Kinase 2
Focal Adhesion Kinase 1
EC 2.7.10.2
Pp125FAK
P125FAK
FADK 1
FRNK
Protein Phosphatase 1, Regulatory Subunit 71
FAK-Related Non-Kinase Polypeptide
Protein-Tyrosine Kinase 2
EC 2.7.10
Location (GRCh37)
8:141668481-142005154
UCSC Genome Browser
Location (GRCh38)
8:140658382-140995055
Host gene
PTK2
Host category
mRNA
Forensic tag(s)
Sudden death from CNS diseases
External database
Transcripts
| ID | Type | Location (GRCh37) | Location (GRCh38) | Length | GC content |
|---|---|---|---|---|---|
| hsa_PTK2_0002900 | Exon-Exon | chr8:141684397-141716304 | chr8:140674298-140706205 | 567 nt | 0.5220 |
| hsa_PTK2_0003000 | Exon-Exon | chr8:141684397-141727808 | chr8:140674298-140717709 | 118 nt | 0.5763 |
| hsa_PTK2_0003100 | Exon-Exon | chr8:141684397-141754866 | chr8:140674298-140744767 | 122 nt | 0.3934 |
| hsa_PTK2_0003200 | Exon-Exon | chr8:141684397-141756959 | chr8:140674298-140746860 | 1292 nt | 0.4822 |
| hsa_PTK2_0003300 | Exon-Exon | chr8:141684397-141762415 | chr8:140674298-140752316 | 396 nt | 0.4924 |
| hsa_PTK2_0003400 | Exon-Exon | chr8:141684397-141771361 | chr8:140674298-140761262 | 308 nt | 0.4968 |
| hsa_PTK2_0003500 | Exon-Exon | chr8:141684397-141774389 | chr8:140674298-140764290 | 103 nt | 0.4757 |
| hsa_PTK2_0003600 | Intron-Exon-Intron | chr8:141684397-141776986 | chr8:140674298-140766887 | 40 nt | 0.4000 |
| hsa_PTK2_0003700 | Exon-Exon | chr8:141684397-141779691 | chr8:140674298-140769592 | 191 nt | 0.4921 |
| hsa_PTK2_0003800 | Exon-Exon | chr8:141684397-141780898 | chr8:140674298-140770799 | 84 nt | 0.4762 |
Showing 141 to 150 of 573 entries
Forensic Context
A study in mice demonstrated that the circPTK2 is induced after oxygen-glucose deprivation and regulates microglia-induced hippocampal neuronal apoptosis via the miR-29b/SOCS-1-JAK2/STAT3-IL-1β axis [Huang et al. DOI:10.3390/cells11091381]. In a separate review, the circPTK2 was similarly noted to be induced after stroke, where it suppresses miR-29b, leading to JAK2/STAT3 activation, IL-1β production, and neuronal apoptosis [Mehta et al. DOI:10.1016/j.pneurobio.2020.101746].