Basic Information
Symbol
circPTK2
RNA Class
circRNA
Alias
Protein Tyrosine Kinase 2
PPP1R71
FAK1
FAK
FADK
Protein Phosphatase 1 Regulatory Subunit 71
Focal Adhesion Kinase-Related Nonkinase
PTK2 Protein Tyrosine Kinase 2
Focal Adhesion Kinase 1
EC 2.7.10.2
Pp125FAK
P125FAK
FADK 1
FRNK
Protein Phosphatase 1, Regulatory Subunit 71
FAK-Related Non-Kinase Polypeptide
Protein-Tyrosine Kinase 2
EC 2.7.10
Location (GRCh37)
8:141668481-142005154
UCSC Genome Browser
Location (GRCh38)
8:140658382-140995055
Host gene
PTK2
Host category
mRNA
Forensic tag(s)
Sudden death from CNS diseases
External database
Transcripts
| ID | Type | Location (GRCh37) | Location (GRCh38) | Length | GC content |
|---|---|---|---|---|---|
| hsa_PTK2_0003900 | Exon-Exon | chr8:141684397-141799625 | chr8:140674298-140789526 | 1624 nt | 0.4692 |
| hsa_chr8_0162100 | Intergenic-Intergenic | chr8:141684774-141690421 | chr8:140674675-140680322 | 250 nt | 0.3640 |
| hsa_PTK2_0004000 | Exon-Exon | chr8:141685529-141753429 | chr8:140675430-140743330 | 998 nt | 0.4790 |
| hsa_PTK2_0004300 | Exon-Intron | chr8:141685559-141697228 | chr8:140675460-140687129 | 277 nt | 0.4404 |
| hsa_PTK2_0004400 | Exon-Exon | chr8:141685559-141711121 | chr8:140675460-140701022 | 138 nt | 0.4928 |
| hsa_PTK2_0004500 | Exon-Exon | chr8:141685559-141727808 | chr8:140675460-140717709 | 40 nt | 0.4000 |
| hsa_PTK2_0004600 | Exon-Exon | chr8:141685559-141753429 | chr8:140675460-140743330 | 46 nt | 0.4130 |
| hsa_PTK2_0004700 | Exon-Exon | chr8:141685559-141756959 | chr8:140675460-140746860 | 395 nt | 0.4278 |
| hsa_PTK2_0004200 | Exon-Exon | chr8:141685559-141840625 | chr8:140675460-140830526 | 2009 nt | 0.4520 |
| hsa_PTK2_0004800 | Intron-Exon-Intron | chr8:141690587-141702497 | chr8:140680488-140692398 | 250 nt | 0.3520 |
Showing 151 to 160 of 573 entries
Forensic Context
A study in mice demonstrated that the circPTK2 is induced after oxygen-glucose deprivation and regulates microglia-induced hippocampal neuronal apoptosis via the miR-29b/SOCS-1-JAK2/STAT3-IL-1β axis [Huang et al. DOI:10.3390/cells11091381]. In a separate review, the circPTK2 was similarly noted to be induced after stroke, where it suppresses miR-29b, leading to JAK2/STAT3 activation, IL-1β production, and neuronal apoptosis [Mehta et al. DOI:10.1016/j.pneurobio.2020.101746].