Basic Information
Symbol
circPTK2
RNA Class
circRNA
Alias
Protein Tyrosine Kinase 2
PPP1R71
FAK1
FAK
FADK
Protein Phosphatase 1 Regulatory Subunit 71
Focal Adhesion Kinase-Related Nonkinase
PTK2 Protein Tyrosine Kinase 2
Focal Adhesion Kinase 1
EC 2.7.10.2
Pp125FAK
P125FAK
FADK 1
FRNK
Protein Phosphatase 1, Regulatory Subunit 71
FAK-Related Non-Kinase Polypeptide
Protein-Tyrosine Kinase 2
EC 2.7.10
Location (GRCh37)
8:141668481-142005154
UCSC Genome Browser
Location (GRCh38)
8:140658382-140995055
Host gene
PTK2
Host category
mRNA
Forensic tag(s)
Sudden death from CNS diseases
External database
Transcripts
| ID | Type | Location (GRCh37) | Location (GRCh38) | Length | GC content |
|---|---|---|---|---|---|
| hsa_PTK2_0005300 | Exon-Exon | chr8:141696731-141712806 | chr8:140686632-140702707 | 333 nt | 0.5015 |
| hsa_PTK2_0005400 | Exon-Exon | chr8:141696731-141716304 | chr8:140686632-140706205 | 420 nt | 0.5095 |
| hsa_PTK2_0005700 | Exon-Exon | chr8:141696731-141727808 | chr8:140686632-140717709 | 307 nt | 0.5309 |
| hsa_PTK2_0005500 | Exon-Exon | chr8:141696731-141745421 | chr8:140686632-140735322 | 604 nt | 0.5265 |
| hsa_PTK2_0005800 | Exon-Exon | chr8:141696731-141745554 | chr8:140686632-140735455 | 63 nt | 0.5238 |
| hsa_PTK2_0005600 | Exon-Exon | chr8:141696731-141749206 | chr8:140686632-140739107 | 827 nt | 0.4982 |
| hsa_PTK2_0005900 | Exon-Exon | chr8:141696731-141753429 | chr8:140686632-140743330 | 63 nt | 0.5238 |
| hsa_PTK2_0006000 | Exon-Exon | chr8:141696731-141754866 | chr8:140686632-140744767 | 333 nt | 0.5015 |
| hsa_PTK2_0006100 | Exon-Exon | chr8:141696731-141756959 | chr8:140686632-140746860 | 107 nt | 0.4673 |
| hsa_PTK2_0006200 | Exon-Exon | chr8:141696731-141762415 | chr8:140686632-140752316 | 91 nt | 0.4396 |
Showing 161 to 170 of 573 entries
Forensic Context
A study in mice demonstrated that the circPTK2 is induced after oxygen-glucose deprivation and regulates microglia-induced hippocampal neuronal apoptosis via the miR-29b/SOCS-1-JAK2/STAT3-IL-1β axis [Huang et al. DOI:10.3390/cells11091381]. In a separate review, the circPTK2 was similarly noted to be induced after stroke, where it suppresses miR-29b, leading to JAK2/STAT3 activation, IL-1β production, and neuronal apoptosis [Mehta et al. DOI:10.1016/j.pneurobio.2020.101746].