Basic Information

Symbol
circPTK2
RNA Class
circRNA
Alias
Protein Tyrosine Kinase 2 PPP1R71 FAK1 FAK FADK Protein Phosphatase 1 Regulatory Subunit 71 Focal Adhesion Kinase-Related Nonkinase PTK2 Protein Tyrosine Kinase 2 Focal Adhesion Kinase 1 EC 2.7.10.2 Pp125FAK P125FAK FADK 1 FRNK Protein Phosphatase 1, Regulatory Subunit 71 FAK-Related Non-Kinase Polypeptide Protein-Tyrosine Kinase 2 EC 2.7.10
Location (GRCh37)
8:141668481-142005154 UCSC Genome Browser
Location (GRCh38)
8:140658382-140995055
UCSC Genome Browser Search in Marker Scope
Host gene
PTK2
Host category
mRNA
Forensic tag(s)
Sudden death from CNS diseases
External database
circbank

Transcripts

ID Type Location (GRCh37) Location (GRCh38) Length GC content
hsa_PTK2_0006300 Exon-Exon chr8:141696731-141771361 chr8:140686632-140761262 69 nt 0.5507
hsa_PTK2_0006400 Exon-Exon chr8:141696731-141772487 chr8:140686632-140762388 119 nt 0.3782
hsa_PTK2_0006500 Exon-Exon chr8:141696731-141774389 chr8:140686632-140764290 205 nt 0.4293
hsa_PTK2_0006600 Exon-Exon chr8:141696731-141779691 chr8:140686632-140769592 218 nt 0.4174
hsa_PTK2_0005100 Exon-Exon chr8:141696731-141780898 chr8:140686632-140770799 1487 nt 0.4586
hsa_PTK2_0006700 Intron-Exon-Intron chr8:141696731-141784729 chr8:140686632-140774630 195 nt 0.5026
hsa_PTK2_0006800 Exon-Exon chr8:141696731-141856777 chr8:140686632-140846678 80 nt 0.4000
hsa_PTK2_0006900 Exon-Exon chr8:141696731-141874498 chr8:140686632-140864399 151 nt 0.3974
hsa_PTK2_0005200 Exon-Exon chr8:141696731-141889736 chr8:140686632-140879637 2367 nt 0.4508
hsa_chr8_0162200 Intergenic-Intergenic chr8:141700973-141701122 chr8:140690874-140691023 150 nt 0.3933
Showing 171 to 180 of 573 entries
Forensic Context

A study in mice demonstrated that the circPTK2 is induced after oxygen-glucose deprivation and regulates microglia-induced hippocampal neuronal apoptosis via the miR-29b/SOCS-1-JAK2/STAT3-IL-1β axis [Huang et al. DOI:10.3390/cells11091381]. In a separate review, the circPTK2 was similarly noted to be induced after stroke, where it suppresses miR-29b, leading to JAK2/STAT3 activation, IL-1β production, and neuronal apoptosis [Mehta et al. DOI:10.1016/j.pneurobio.2020.101746].