Basic Information

Symbol
circPTK2
RNA Class
circRNA
Alias
Protein Tyrosine Kinase 2 PPP1R71 FAK1 FAK FADK Protein Phosphatase 1 Regulatory Subunit 71 Focal Adhesion Kinase-Related Nonkinase PTK2 Protein Tyrosine Kinase 2 Focal Adhesion Kinase 1 EC 2.7.10.2 Pp125FAK P125FAK FADK 1 FRNK Protein Phosphatase 1, Regulatory Subunit 71 FAK-Related Non-Kinase Polypeptide Protein-Tyrosine Kinase 2 EC 2.7.10
Location (GRCh37)
8:141668481-142005154 UCSC Genome Browser
Location (GRCh38)
8:140658382-140995055
UCSC Genome Browser Search in Marker Scope
Host gene
PTK2
Host category
mRNA
Forensic tag(s)
Sudden death from CNS diseases
External database
circbank

Transcripts

ID Type Location (GRCh37) Location (GRCh38) Length GC content
hsa_PTK2_0007000 Intron-Exon-Intron chr8:141701705-141900868 chr8:140691606-140890769 119 nt 0.4790
hsa_PTK2_0007100 Intron-Intron chr8:141705324-141705837 chr8:140695225-140695738 514 nt 0.4767
hsa_PTK2_0007200 Intron-Exon-Intron chr8:141710806-141755905 chr8:140700707-140745806 2204 nt 0.4152
hsa_PTK2_0008000 Exon-Exon chr8:141710990-141745421 chr8:140700891-140735322 72 nt 0.5417
hsa_PTK2_0007900 Exon-Exon chr8:141710990-141745554 chr8:140700891-140735455 674 nt 0.5089
hsa_PTK2_0008100 Exon-Exon chr8:141710990-141749206 chr8:140700891-140739107 407 nt 0.4865
hsa_PTK2_0008200 Exon-Exon chr8:141710990-141753429 chr8:140700891-140743330 371 nt 0.4663
hsa_PTK2_0008300 Exon-Exon chr8:141710990-141754866 chr8:140700891-140744767 335 nt 0.4687
hsa_PTK2_0008400 Exon-Exon chr8:141710990-141756959 chr8:140700891-140746860 233 nt 0.4721
hsa_PTK2_0008500 Exon-Exon chr8:141710990-141771361 chr8:140700891-140761262 230 nt 0.4478
Showing 181 to 190 of 573 entries
Forensic Context

A study in mice demonstrated that the circPTK2 is induced after oxygen-glucose deprivation and regulates microglia-induced hippocampal neuronal apoptosis via the miR-29b/SOCS-1-JAK2/STAT3-IL-1β axis [Huang et al. DOI:10.3390/cells11091381]. In a separate review, the circPTK2 was similarly noted to be induced after stroke, where it suppresses miR-29b, leading to JAK2/STAT3 activation, IL-1β production, and neuronal apoptosis [Mehta et al. DOI:10.1016/j.pneurobio.2020.101746].