Basic Information
Symbol
circPTK2
RNA Class
circRNA
Alias
Protein Tyrosine Kinase 2
PPP1R71
FAK1
FAK
FADK
Protein Phosphatase 1 Regulatory Subunit 71
Focal Adhesion Kinase-Related Nonkinase
PTK2 Protein Tyrosine Kinase 2
Focal Adhesion Kinase 1
EC 2.7.10.2
Pp125FAK
P125FAK
FADK 1
FRNK
Protein Phosphatase 1, Regulatory Subunit 71
FAK-Related Non-Kinase Polypeptide
Protein-Tyrosine Kinase 2
EC 2.7.10
Location (GRCh37)
8:141668481-142005154
UCSC Genome Browser
Location (GRCh38)
8:140658382-140995055
Host gene
PTK2
Host category
mRNA
Forensic tag(s)
Sudden death from CNS diseases
External database
Transcripts
| ID | Type | Location (GRCh37) | Location (GRCh38) | Length | GC content |
|---|---|---|---|---|---|
| hsa_PTK2_0002400 | Exon-Exon | chr8:141684397-141684503 | chr8:140674298-140674404 | 107 nt | 0.6168 |
| hsa_PTK2_0002500 | Exon-Exon | chr8:141684397-141685598 | chr8:140674298-140675499 | 177 nt | 0.5254 |
| hsa_PTK2_0002600 | Exon-Exon | chr8:141684397-141696793 | chr8:140674298-140686694 | 240 nt | 0.5250 |
| hsa_PTK2_0004100 | Exon-Exon | chr8:141685559-141935848 | chr8:140675460-140925749 | 2723 nt | 0.4513 |
| hsa_PTK2_0004900 | Exon-Exon | chr8:141696731-141810675 | chr8:140686632-140800576 | 1587 nt | 0.4657 |
| hsa_PTK2_0005000 | Exon-Exon | chr8:141696731-141935848 | chr8:140686632-140925749 | 2683 nt | 0.4521 |
| hsa_PTK2_0007300 | Exon-Exon | chr8:141710990-141712806 | chr8:140700891-140702707 | 270 nt | 0.4963 |
| hsa_PTK2_0007400 | Exon-Exon | chr8:141710990-141716304 | chr8:140700891-140706205 | 357 nt | 0.5070 |
| hsa_PTK2_0007500 | Exon-Exon | chr8:141710990-141727808 | chr8:140700891-140717709 | 469 nt | 0.5245 |
| hsa_PTK2_0007600 | Exon-Exon | chr8:141710990-141762415 | chr8:140700891-140752316 | 1167 nt | 0.4653 |
Showing 11 to 20 of 573 entries
Forensic Context
A study in mice demonstrated that the circPTK2 is induced after oxygen-glucose deprivation and regulates microglia-induced hippocampal neuronal apoptosis via the miR-29b/SOCS-1-JAK2/STAT3-IL-1β axis [Huang et al. DOI:10.3390/cells11091381]. In a separate review, the circPTK2 was similarly noted to be induced after stroke, where it suppresses miR-29b, leading to JAK2/STAT3 activation, IL-1β production, and neuronal apoptosis [Mehta et al. DOI:10.1016/j.pneurobio.2020.101746].