Basic Information
Symbol
circPTK2
RNA Class
circRNA
Alias
Protein Tyrosine Kinase 2
PPP1R71
FAK1
FAK
FADK
Protein Phosphatase 1 Regulatory Subunit 71
Focal Adhesion Kinase-Related Nonkinase
PTK2 Protein Tyrosine Kinase 2
Focal Adhesion Kinase 1
EC 2.7.10.2
Pp125FAK
P125FAK
FADK 1
FRNK
Protein Phosphatase 1, Regulatory Subunit 71
FAK-Related Non-Kinase Polypeptide
Protein-Tyrosine Kinase 2
EC 2.7.10
Location (GRCh37)
8:141668481-142005154
UCSC Genome Browser
Location (GRCh38)
8:140658382-140995055
Host gene
PTK2
Host category
mRNA
Forensic tag(s)
Sudden death from CNS diseases
External database
Transcripts
| ID | Type | Location (GRCh37) | Location (GRCh38) | Length | GC content |
|---|---|---|---|---|---|
| hsa_PTK2_0008600 | Exon-Exon | chr8:141710990-141772487 | chr8:140700891-140762388 | 153 nt | 0.4706 |
| hsa_PTK2_0008800 | Exon-Exon | chr8:141710990-141779691 | chr8:140700891-140769592 | 138 nt | 0.4783 |
| hsa_PTK2_0008900 | Exon-Exon | chr8:141710990-141780898 | chr8:140700891-140770799 | 84 nt | 0.4762 |
| hsa_PTK2_0009000 | Exon-Exon | chr8:141710990-141874498 | chr8:140700891-140864399 | 300 nt | 0.4133 |
| hsa_PTK2_0009100 | Exon-Exon | chr8:141710990-141889736 | chr8:140700891-140879637 | 198 nt | 0.3889 |
| hsa_PTK2_0009200 | Exon-Exon | chr8:141710990-141900702 | chr8:140700891-140890603 | 193 nt | 0.4974 |
| hsa_PTK2_0009300 | Exon-Exon | chr8:141710990-141900868 | chr8:140700891-140890769 | 138 nt | 0.4783 |
| hsa_PTK2_0009700 | Exon-Exon | chr8:141712669-141753429 | chr8:140702570-140743330 | 733 nt | 0.4816 |
| hsa_PTK2_0009900 | Exon-Exon | chr8:141712669-141754866 | chr8:140702570-140744767 | 116 nt | 0.3879 |
| hsa_PTK2_0009800 | Exon-Exon | chr8:141712669-141756959 | chr8:140702570-140746860 | 950 nt | 0.4663 |
Showing 191 to 200 of 573 entries
Forensic Context
A study in mice demonstrated that the circPTK2 is induced after oxygen-glucose deprivation and regulates microglia-induced hippocampal neuronal apoptosis via the miR-29b/SOCS-1-JAK2/STAT3-IL-1β axis [Huang et al. DOI:10.3390/cells11091381]. In a separate review, the circPTK2 was similarly noted to be induced after stroke, where it suppresses miR-29b, leading to JAK2/STAT3 activation, IL-1β production, and neuronal apoptosis [Mehta et al. DOI:10.1016/j.pneurobio.2020.101746].