Basic Information

Symbol
circPTK2
RNA Class
circRNA
Alias
Protein Tyrosine Kinase 2 PPP1R71 FAK1 FAK FADK Protein Phosphatase 1 Regulatory Subunit 71 Focal Adhesion Kinase-Related Nonkinase PTK2 Protein Tyrosine Kinase 2 Focal Adhesion Kinase 1 EC 2.7.10.2 Pp125FAK P125FAK FADK 1 FRNK Protein Phosphatase 1, Regulatory Subunit 71 FAK-Related Non-Kinase Polypeptide Protein-Tyrosine Kinase 2 EC 2.7.10
Location (GRCh37)
8:141668481-142005154 UCSC Genome Browser
Location (GRCh38)
8:140658382-140995055
UCSC Genome Browser Search in Marker Scope
Host gene
PTK2
Host category
mRNA
Forensic tag(s)
Sudden death from CNS diseases
External database
circbank

Transcripts

ID Type Location (GRCh37) Location (GRCh38) Length GC content
hsa_PTK2_0010000 Exon-Exon chr8:141712749-141749167 chr8:140702650-140739068 109 nt 0.4679
hsa_PTK2_0010200 Exon-Exon chr8:141716218-141727808 chr8:140706119-140717709 199 nt 0.5628
hsa_PTK2_0010400 Exon-Exon chr8:141716218-141745376 chr8:140706119-140735277 114 nt 0.5088
hsa_PTK2_0010300 Exon-Exon chr8:141716218-141753429 chr8:140706119-140743330 595 nt 0.4773
hsa_PTK2_0010500 Exon-Exon chr8:141716218-141756959 chr8:140706119-140746860 107 nt 0.4486
hsa_PTK2_0010600 Exon-Exon chr8:141716218-141774389 chr8:140706119-140764290 240 nt 0.3875
hsa_PTK2_0010700 Intron-Intron chr8:141720376-141721296 chr8:140710277-140711197 921 nt 0.4625
hsa_PTK2_0010800 Intron-Intron chr8:141726372-141726589 chr8:140716273-140716490 218 nt 0.4266
hsa_chr8_0162300 Intergenic-Intergenic chr8:141727298-141727956 chr8:140717199-140717857 659 nt 0.4355
hsa_PTK2_0011600 Exon-Exon chr8:141727697-141749206 chr8:140717598-140739107 202 nt 0.5000
Showing 201 to 210 of 573 entries
Forensic Context

A study in mice demonstrated that the circPTK2 is induced after oxygen-glucose deprivation and regulates microglia-induced hippocampal neuronal apoptosis via the miR-29b/SOCS-1-JAK2/STAT3-IL-1β axis [Huang et al. DOI:10.3390/cells11091381]. In a separate review, the circPTK2 was similarly noted to be induced after stroke, where it suppresses miR-29b, leading to JAK2/STAT3 activation, IL-1β production, and neuronal apoptosis [Mehta et al. DOI:10.1016/j.pneurobio.2020.101746].