Basic Information

Symbol
circPTK2
RNA Class
circRNA
Alias
Protein Tyrosine Kinase 2 PPP1R71 FAK1 FAK FADK Protein Phosphatase 1 Regulatory Subunit 71 Focal Adhesion Kinase-Related Nonkinase PTK2 Protein Tyrosine Kinase 2 Focal Adhesion Kinase 1 EC 2.7.10.2 Pp125FAK P125FAK FADK 1 FRNK Protein Phosphatase 1, Regulatory Subunit 71 FAK-Related Non-Kinase Polypeptide Protein-Tyrosine Kinase 2 EC 2.7.10
Location (GRCh37)
8:141668481-142005154 UCSC Genome Browser
Location (GRCh38)
8:140658382-140995055
UCSC Genome Browser Search in Marker Scope
Host gene
PTK2
Host category
mRNA
Forensic tag(s)
Sudden death from CNS diseases
External database
circbank

Transcripts

ID Type Location (GRCh37) Location (GRCh38) Length GC content
hsa_PTK2_0011700 Exon-Exon chr8:141727697-141753429 chr8:140717598-140743330 303 nt 0.4620
hsa_PTK2_0011500 Intron-Exon-Intron chr8:141727697-141756973 chr8:140717598-140746874 739 nt 0.4479
hsa_PTK2_0011800 Exon-Exon chr8:141727697-141762415 chr8:140717598-140752316 402 nt 0.4900
hsa_PTK2_0011900 Exon-Exon chr8:141727697-141771361 chr8:140717598-140761262 118 nt 0.5932
hsa_PTK2_0012000 Exon-Exon chr8:141727697-141772487 chr8:140717598-140762388 223 nt 0.4843
hsa_PTK2_0012100 Exon-Exon chr8:141727697-141813749 chr8:140717598-140803650 108 nt 0.4352
hsa_PTK2_0012200 Exon-Exon chr8:141727697-141840625 chr8:140717598-140830526 167 nt 0.4970
hsa_PTK2_0012300 Exon-Exon chr8:141727697-141856777 chr8:140717598-140846678 80 nt 0.4000
hsa_PTK2_0012400 Exon-Exon chr8:141727697-141874498 chr8:140717598-140864399 1819 nt 0.4283
hsa_PTK2_0011300 Exon-Exon chr8:141727697-141889736 chr8:140717598-140879637 1947 nt 0.4381
Showing 211 to 220 of 573 entries
Forensic Context

A study in mice demonstrated that the circPTK2 is induced after oxygen-glucose deprivation and regulates microglia-induced hippocampal neuronal apoptosis via the miR-29b/SOCS-1-JAK2/STAT3-IL-1β axis [Huang et al. DOI:10.3390/cells11091381]. In a separate review, the circPTK2 was similarly noted to be induced after stroke, where it suppresses miR-29b, leading to JAK2/STAT3 activation, IL-1β production, and neuronal apoptosis [Mehta et al. DOI:10.1016/j.pneurobio.2020.101746].