Basic Information

Symbol
circPTK2
RNA Class
circRNA
Alias
Protein Tyrosine Kinase 2 PPP1R71 FAK1 FAK FADK Protein Phosphatase 1 Regulatory Subunit 71 Focal Adhesion Kinase-Related Nonkinase PTK2 Protein Tyrosine Kinase 2 Focal Adhesion Kinase 1 EC 2.7.10.2 Pp125FAK P125FAK FADK 1 FRNK Protein Phosphatase 1, Regulatory Subunit 71 FAK-Related Non-Kinase Polypeptide Protein-Tyrosine Kinase 2 EC 2.7.10
Location (GRCh37)
8:141668481-142005154 UCSC Genome Browser
Location (GRCh38)
8:140658382-140995055
UCSC Genome Browser Search in Marker Scope
Host gene
PTK2
Host category
mRNA
Forensic tag(s)
Sudden death from CNS diseases
External database
circbank

Transcripts

ID Type Location (GRCh37) Location (GRCh38) Length GC content
hsa_PTK2_0012500 Exon-Exon chr8:141727697-141900868 chr8:140717598-140890769 193 nt 0.5078
hsa_PTK2_0011400 Intron-Exon-Intron chr8:141727697-141922566 chr8:140717598-140912467 250 nt 0.4520
hsa_chr8_0162400 Intergenic-Intergenic chr8:141738082-141738899 chr8:140727983-140728800 818 nt 0.4499
hsa_chr8_0162500 Intergenic-Intergenic chr8:141738207-141738811 chr8:140728108-140728712 605 nt 0.4231
hsa_PTK2_0012600 Intron-Intron chr8:141739850-141740719 chr8:140729751-140730620 870 nt 0.3851
hsa_chr8_0162600 Intergenic-Intergenic chr8:141741337-141741762 chr8:140731238-140731663 426 nt 0.3803
hsa_PTK2_0012700 Intron-Exon-Intron chr8:141744723-141762415 chr8:140734624-140752316 85 nt 0.4118
hsa_PTK2_0013100 Exon-Exon chr8:141745350-141745554 chr8:140735251-140735455 205 nt 0.4732
hsa_PTK2_0013200 Exon-Exon chr8:141745350-141753429 chr8:140735251-140743330 396 nt 0.4343
hsa_PTK2_0013400 Exon-Exon chr8:141745350-141754866 chr8:140735251-140744767 122 nt 0.4016
Showing 221 to 230 of 573 entries
Forensic Context

A study in mice demonstrated that the circPTK2 is induced after oxygen-glucose deprivation and regulates microglia-induced hippocampal neuronal apoptosis via the miR-29b/SOCS-1-JAK2/STAT3-IL-1β axis [Huang et al. DOI:10.3390/cells11091381]. In a separate review, the circPTK2 was similarly noted to be induced after stroke, where it suppresses miR-29b, leading to JAK2/STAT3 activation, IL-1β production, and neuronal apoptosis [Mehta et al. DOI:10.1016/j.pneurobio.2020.101746].