Basic Information
Symbol
circPTK2
RNA Class
circRNA
Alias
Protein Tyrosine Kinase 2
PPP1R71
FAK1
FAK
FADK
Protein Phosphatase 1 Regulatory Subunit 71
Focal Adhesion Kinase-Related Nonkinase
PTK2 Protein Tyrosine Kinase 2
Focal Adhesion Kinase 1
EC 2.7.10.2
Pp125FAK
P125FAK
FADK 1
FRNK
Protein Phosphatase 1, Regulatory Subunit 71
FAK-Related Non-Kinase Polypeptide
Protein-Tyrosine Kinase 2
EC 2.7.10
Location (GRCh37)
8:141668481-142005154
UCSC Genome Browser
Location (GRCh38)
8:140658382-140995055
Host gene
PTK2
Host category
mRNA
Forensic tag(s)
Sudden death from CNS diseases
External database
Transcripts
| ID | Type | Location (GRCh37) | Location (GRCh38) | Length | GC content |
|---|---|---|---|---|---|
| hsa_PTK2_0013500 | Exon-Exon | chr8:141745350-141756959 | chr8:140735251-140746860 | 306 nt | 0.4641 |
| hsa_PTK2_0013600 | Exon-Exon | chr8:141745350-141771361 | chr8:140735251-140761262 | 303 nt | 0.4455 |
| hsa_PTK2_0013300 | Exon-Exon | chr8:141745350-141772487 | chr8:140735251-140762388 | 817 nt | 0.4186 |
| hsa_PTK2_0013800 | Exon-Exon | chr8:141745350-141779691 | chr8:140735251-140769592 | 188 nt | 0.3723 |
| hsa_PTK2_0013900 | Exon-Exon | chr8:141745350-141780898 | chr8:140735251-140770799 | 84 nt | 0.4762 |
| hsa_PTK2_0014000 | Exon-Exon | chr8:141745350-141803483 | chr8:140735251-140793384 | 976 nt | 0.4252 |
| hsa_PTK2_0014100 | Exon-Exon | chr8:141745350-141813749 | chr8:140735251-140803650 | 90 nt | 0.4000 |
| hsa_PTK2_0014200 | Exon-Exon | chr8:141745350-141829119 | chr8:140735251-140819020 | 1421 nt | 0.4293 |
| hsa_PTK2_0014300 | Exon-Exon | chr8:141745350-141840625 | chr8:140735251-140830526 | 55 nt | 0.3273 |
| hsa_PTK2_0014400 | Exon-Exon | chr8:141745350-141856421 | chr8:140735251-140846322 | 323 nt | 0.4396 |
Showing 231 to 240 of 573 entries
Forensic Context
A study in mice demonstrated that the circPTK2 is induced after oxygen-glucose deprivation and regulates microglia-induced hippocampal neuronal apoptosis via the miR-29b/SOCS-1-JAK2/STAT3-IL-1β axis [Huang et al. DOI:10.3390/cells11091381]. In a separate review, the circPTK2 was similarly noted to be induced after stroke, where it suppresses miR-29b, leading to JAK2/STAT3 activation, IL-1β production, and neuronal apoptosis [Mehta et al. DOI:10.1016/j.pneurobio.2020.101746].