Basic Information
Symbol
circPTK2
RNA Class
circRNA
Alias
Protein Tyrosine Kinase 2
PPP1R71
FAK1
FAK
FADK
Protein Phosphatase 1 Regulatory Subunit 71
Focal Adhesion Kinase-Related Nonkinase
PTK2 Protein Tyrosine Kinase 2
Focal Adhesion Kinase 1
EC 2.7.10.2
Pp125FAK
P125FAK
FADK 1
FRNK
Protein Phosphatase 1, Regulatory Subunit 71
FAK-Related Non-Kinase Polypeptide
Protein-Tyrosine Kinase 2
EC 2.7.10
Location (GRCh37)
8:141668481-142005154
UCSC Genome Browser
Location (GRCh38)
8:140658382-140995055
Host gene
PTK2
Host category
mRNA
Forensic tag(s)
Sudden death from CNS diseases
External database
Transcripts
| ID | Type | Location (GRCh37) | Location (GRCh38) | Length | GC content |
|---|---|---|---|---|---|
| hsa_PTK2_0016300 | Exon-Exon | chr8:141749117-141762405 | chr8:140739018-140752306 | 90 nt | 0.4000 |
| hsa_PTK2_0016400 | Exon-Exon | chr8:141749117-141762412 | chr8:140739018-140752313 | 172 nt | 0.4012 |
| hsa_PTK2_0016200 | Exon-Exon | chr8:141749117-141772487 | chr8:140739018-140762388 | 612 nt | 0.4003 |
| hsa_PTK2_0016500 | Exon-Exon | chr8:141749117-141774389 | chr8:140739018-140764290 | 147 nt | 0.3810 |
| hsa_PTK2_0016600 | Exon-Exon | chr8:141749117-141779691 | chr8:140739018-140769592 | 310 nt | 0.3871 |
| hsa_PTK2_0016700 | Exon-Exon | chr8:141749117-141780898 | chr8:140739018-140770799 | 1894 nt | 0.3944 |
| hsa_PTK2_0016800 | Intron-Exon-Intron | chr8:141749117-141784729 | chr8:140739018-140774630 | 90 nt | 0.4000 |
| hsa_PTK2_0016900 | Exon-Exon | chr8:141749117-141799625 | chr8:140739018-140789526 | 90 nt | 0.4000 |
| hsa_PTK2_0017000 | Exon-Exon | chr8:141749117-141803483 | chr8:140739018-140793384 | 771 nt | 0.4125 |
| hsa_PTK2_0017100 | Exon-Exon | chr8:141749117-141813749 | chr8:140739018-140803650 | 547 nt | 0.4132 |
Showing 251 to 260 of 573 entries
Forensic Context
A study in mice demonstrated that the circPTK2 is induced after oxygen-glucose deprivation and regulates microglia-induced hippocampal neuronal apoptosis via the miR-29b/SOCS-1-JAK2/STAT3-IL-1β axis [Huang et al. DOI:10.3390/cells11091381]. In a separate review, the circPTK2 was similarly noted to be induced after stroke, where it suppresses miR-29b, leading to JAK2/STAT3 activation, IL-1β production, and neuronal apoptosis [Mehta et al. DOI:10.1016/j.pneurobio.2020.101746].