Basic Information

Symbol
circPTK2
RNA Class
circRNA
Alias
Protein Tyrosine Kinase 2 PPP1R71 FAK1 FAK FADK Protein Phosphatase 1 Regulatory Subunit 71 Focal Adhesion Kinase-Related Nonkinase PTK2 Protein Tyrosine Kinase 2 Focal Adhesion Kinase 1 EC 2.7.10.2 Pp125FAK P125FAK FADK 1 FRNK Protein Phosphatase 1, Regulatory Subunit 71 FAK-Related Non-Kinase Polypeptide Protein-Tyrosine Kinase 2 EC 2.7.10
Location (GRCh37)
8:141668481-142005154 UCSC Genome Browser
Location (GRCh38)
8:140658382-140995055
UCSC Genome Browser Search in Marker Scope
Host gene
PTK2
Host category
mRNA
Forensic tag(s)
Sudden death from CNS diseases
External database
circbank

Transcripts

ID Type Location (GRCh37) Location (GRCh38) Length GC content
hsa_PTK2_0017200 Exon-Exon chr8:141749117-141874498 chr8:140739018-140864399 387 nt 0.3928
hsa_PTK2_0017300 Intron-Exon-Intron chr8:141749117-141884629 chr8:140739018-140874530 246 nt 0.3455
hsa_PTK2_0017400 Exon-Exon chr8:141749117-141900702 chr8:140739018-140890603 1563 nt 0.4146
hsa_PTK2_0017500 Exon-Exon chr8:141749117-141900867 chr8:140739018-140890768 1728 nt 0.4149
hsa_PTK2_0017600 Exon-Exon chr8:141749117-141900868 chr8:140739018-140890769 418 nt 0.4187
hsa_PTK2_0016000 Intron-Exon-Intron chr8:141749117-141922566 chr8:140739018-140912467 250 nt 0.3720
hsa_PTK2_0017700 Exon-Exon chr8:141749117-141931231 chr8:140739018-140921132 90 nt 0.4000
hsa_PTK2_0018300 Exon-Exon chr8:141753329-141754866 chr8:140743230-140744767 217 nt 0.3871
hsa_PTK2_0018400 Exon-Exon chr8:141753329-141772487 chr8:140743230-140762388 339 nt 0.4012
hsa_PTK2_0018600 Intron-Exon-Intron chr8:141753329-141774985 chr8:140743230-140764886 1175 nt 0.3685
Showing 261 to 270 of 573 entries
Forensic Context

A study in mice demonstrated that the circPTK2 is induced after oxygen-glucose deprivation and regulates microglia-induced hippocampal neuronal apoptosis via the miR-29b/SOCS-1-JAK2/STAT3-IL-1β axis [Huang et al. DOI:10.3390/cells11091381]. In a separate review, the circPTK2 was similarly noted to be induced after stroke, where it suppresses miR-29b, leading to JAK2/STAT3 activation, IL-1β production, and neuronal apoptosis [Mehta et al. DOI:10.1016/j.pneurobio.2020.101746].