Basic Information
Symbol
circPTK2
RNA Class
circRNA
Alias
Protein Tyrosine Kinase 2
PPP1R71
FAK1
FAK
FADK
Protein Phosphatase 1 Regulatory Subunit 71
Focal Adhesion Kinase-Related Nonkinase
PTK2 Protein Tyrosine Kinase 2
Focal Adhesion Kinase 1
EC 2.7.10.2
Pp125FAK
P125FAK
FADK 1
FRNK
Protein Phosphatase 1, Regulatory Subunit 71
FAK-Related Non-Kinase Polypeptide
Protein-Tyrosine Kinase 2
EC 2.7.10
Location (GRCh37)
8:141668481-142005154
UCSC Genome Browser
Location (GRCh38)
8:140658382-140995055
Host gene
PTK2
Host category
mRNA
Forensic tag(s)
Sudden death from CNS diseases
External database
Transcripts
| ID | Type | Location (GRCh37) | Location (GRCh38) | Length | GC content |
|---|---|---|---|---|---|
| hsa_PTK2_0018700 | Exon-Exon | chr8:141753329-141779691 | chr8:140743230-140769592 | 597 nt | 0.3970 |
| hsa_PTK2_0018800 | Exon-Exon | chr8:141753329-141780898 | chr8:140743230-140770799 | 84 nt | 0.4762 |
| hsa_PTK2_0018900 | Exon-Exon | chr8:141753329-141799625 | chr8:140743230-140789526 | 217 nt | 0.3871 |
| hsa_PTK2_0019000 | Exon-Exon | chr8:141753329-141840625 | chr8:140743230-140830526 | 202 nt | 0.3515 |
| hsa_PTK2_0018200 | Exon-Exon | chr8:141753329-141889736 | chr8:140743230-140879637 | 1540 nt | 0.4253 |
| hsa_PTK2_0019100 | Exon-Exon | chr8:141753329-141900868 | chr8:140743230-140890769 | 101 nt | 0.3861 |
| hsa_PTK2_0019400 | Intron-Exon-Intron | chr8:141754751-141777918 | chr8:140744652-140767819 | 250 nt | 0.3280 |
| hsa_PTK2_0019500 | Exon-Exon | chr8:141754751-141900868 | chr8:140744652-140890769 | 116 nt | 0.3879 |
| hsa_PTK2_0019600 | Intron-Exon | chr8:141756022-141757099 | chr8:140745923-140747000 | 241 nt | 0.4232 |
| hsa_PTK2_0019700 | Intron-Exon | chr8:141756491-141756959 | chr8:140746392-140746860 | 469 nt | 0.3881 |
Showing 271 to 280 of 573 entries
Forensic Context
A study in mice demonstrated that the circPTK2 is induced after oxygen-glucose deprivation and regulates microglia-induced hippocampal neuronal apoptosis via the miR-29b/SOCS-1-JAK2/STAT3-IL-1β axis [Huang et al. DOI:10.3390/cells11091381]. In a separate review, the circPTK2 was similarly noted to be induced after stroke, where it suppresses miR-29b, leading to JAK2/STAT3 activation, IL-1β production, and neuronal apoptosis [Mehta et al. DOI:10.1016/j.pneurobio.2020.101746].