Basic Information
Symbol
circPTK2
RNA Class
circRNA
Alias
Protein Tyrosine Kinase 2
PPP1R71
FAK1
FAK
FADK
Protein Phosphatase 1 Regulatory Subunit 71
Focal Adhesion Kinase-Related Nonkinase
PTK2 Protein Tyrosine Kinase 2
Focal Adhesion Kinase 1
EC 2.7.10.2
Pp125FAK
P125FAK
FADK 1
FRNK
Protein Phosphatase 1, Regulatory Subunit 71
FAK-Related Non-Kinase Polypeptide
Protein-Tyrosine Kinase 2
EC 2.7.10
Location (GRCh37)
8:141668481-142005154
UCSC Genome Browser
Location (GRCh38)
8:140658382-140995055
Host gene
PTK2
Host category
mRNA
Forensic tag(s)
Sudden death from CNS diseases
External database
Transcripts
| ID | Type | Location (GRCh37) | Location (GRCh38) | Length | GC content |
|---|---|---|---|---|---|
| hsa_PTK2_0020000 | Exon-Exon | chr8:141756859-141762415 | chr8:140746760-140752316 | 271 nt | 0.4391 |
| hsa_PTK2_0020100 | Exon-Exon | chr8:141756859-141771361 | chr8:140746760-140761262 | 107 nt | 0.4673 |
| hsa_PTK2_0019800 | Exon-Exon | chr8:141756859-141772487 | chr8:140746760-140762388 | 305 nt | 0.4098 |
| hsa_PTK2_0020300 | Intron-Exon-Intron | chr8:141756859-141774985 | chr8:140746760-140764886 | 284 nt | 0.4155 |
| hsa_PTK2_0020400 | Intron-Exon-Intron | chr8:141756859-141776986 | chr8:140746760-140766887 | 199 nt | 0.4171 |
| hsa_PTK2_0020500 | Exon-Exon | chr8:141756859-141779691 | chr8:140746760-140769592 | 90 nt | 0.3556 |
| hsa_PTK2_0020600 | Exon-Exon | chr8:141756859-141799625 | chr8:140746760-140789526 | 200 nt | 0.4600 |
| hsa_PTK2_0020700 | Exon-Exon | chr8:141756859-141810675 | chr8:140746760-140800576 | 107 nt | 0.4579 |
| hsa_PTK2_0020800 | Intron-Exon-Intron | chr8:141756859-141837196 | chr8:140746760-140827097 | 207 nt | 0.4203 |
| hsa_PTK2_0020900 | Exon-Exon | chr8:141756859-141856777 | chr8:140746760-140846678 | 199 nt | 0.4171 |
Showing 281 to 290 of 573 entries
Forensic Context
A study in mice demonstrated that the circPTK2 is induced after oxygen-glucose deprivation and regulates microglia-induced hippocampal neuronal apoptosis via the miR-29b/SOCS-1-JAK2/STAT3-IL-1β axis [Huang et al. DOI:10.3390/cells11091381]. In a separate review, the circPTK2 was similarly noted to be induced after stroke, where it suppresses miR-29b, leading to JAK2/STAT3 activation, IL-1β production, and neuronal apoptosis [Mehta et al. DOI:10.1016/j.pneurobio.2020.101746].