Basic Information
Symbol
circPTK2
RNA Class
circRNA
Alias
Protein Tyrosine Kinase 2
PPP1R71
FAK1
FAK
FADK
Protein Phosphatase 1 Regulatory Subunit 71
Focal Adhesion Kinase-Related Nonkinase
PTK2 Protein Tyrosine Kinase 2
Focal Adhesion Kinase 1
EC 2.7.10.2
Pp125FAK
P125FAK
FADK 1
FRNK
Protein Phosphatase 1, Regulatory Subunit 71
FAK-Related Non-Kinase Polypeptide
Protein-Tyrosine Kinase 2
EC 2.7.10
Location (GRCh37)
8:141668481-142005154
UCSC Genome Browser
Location (GRCh38)
8:140658382-140995055
Host gene
PTK2
Host category
mRNA
Forensic tag(s)
Sudden death from CNS diseases
External database
Transcripts
| ID | Type | Location (GRCh37) | Location (GRCh38) | Length | GC content |
|---|---|---|---|---|---|
| hsa_PTK2_0008700 | Exon-Exon | chr8:141710990-141774389 | chr8:140700891-140764290 | 1343 nt | 0.4527 |
| hsa_PTK2_0007700 | Exon-Exon | chr8:141710990-141856421 | chr8:140700891-140846322 | 1969 nt | 0.4500 |
| hsa_PTK2_0007800 | Exon-Exon | chr8:141710990-141856777 | chr8:140700891-140846678 | 2049 nt | 0.4480 |
| hsa_PTK2_0009400 | Exon-Exon | chr8:141712669-141716304 | chr8:140702570-140706205 | 225 nt | 0.5156 |
| hsa_PTK2_0009500 | Exon-Exon | chr8:141712669-141771361 | chr8:140702570-140761262 | 1133 nt | 0.4554 |
| hsa_PTK2_0009600 | Exon-Exon | chr8:141712669-141813749 | chr8:140702570-140803650 | 1500 nt | 0.4587 |
| hsa_PTK2_0010100 | Exon-Exon | chr8:141716218-141889736 | chr8:140706119-140879637 | 2034 nt | 0.4425 |
| hsa_PTK2_0010900 | Exon-Exon | chr8:141727697-141754866 | chr8:140717598-140744767 | 624 nt | 0.4519 |
| hsa_PTK2_0011000 | Exon-Exon | chr8:141727697-141756959 | chr8:140717598-140746860 | 725 nt | 0.4510 |
| hsa_PTK2_0011100 | Exon-Exon | chr8:141727697-141774389 | chr8:140717598-140764290 | 965 nt | 0.4352 |
Showing 21 to 30 of 573 entries
Forensic Context
A study in mice demonstrated that the circPTK2 is induced after oxygen-glucose deprivation and regulates microglia-induced hippocampal neuronal apoptosis via the miR-29b/SOCS-1-JAK2/STAT3-IL-1β axis [Huang et al. DOI:10.3390/cells11091381]. In a separate review, the circPTK2 was similarly noted to be induced after stroke, where it suppresses miR-29b, leading to JAK2/STAT3 activation, IL-1β production, and neuronal apoptosis [Mehta et al. DOI:10.1016/j.pneurobio.2020.101746].