Basic Information
Symbol
circPTK2
RNA Class
circRNA
Alias
Protein Tyrosine Kinase 2
PPP1R71
FAK1
FAK
FADK
Protein Phosphatase 1 Regulatory Subunit 71
Focal Adhesion Kinase-Related Nonkinase
PTK2 Protein Tyrosine Kinase 2
Focal Adhesion Kinase 1
EC 2.7.10.2
Pp125FAK
P125FAK
FADK 1
FRNK
Protein Phosphatase 1, Regulatory Subunit 71
FAK-Related Non-Kinase Polypeptide
Protein-Tyrosine Kinase 2
EC 2.7.10
Location (GRCh37)
8:141668481-142005154
UCSC Genome Browser
Location (GRCh38)
8:140658382-140995055
Host gene
PTK2
Host category
mRNA
Forensic tag(s)
Sudden death from CNS diseases
External database
Transcripts
| ID | Type | Location (GRCh37) | Location (GRCh38) | Length | GC content |
|---|---|---|---|---|---|
| hsa_PTK2_0021000 | Exon-Exon | chr8:141756859-141874498 | chr8:140746760-140864399 | 237 nt | 0.3797 |
| hsa_PTK2_0021100 | Exon-Exon | chr8:141756859-141900868 | chr8:140746760-140890769 | 1422 nt | 0.4198 |
| hsa_PTK2_0019900 | Exon-Exon | chr8:141756859-141931231 | chr8:140746760-140921132 | 1869 nt | 0.4371 |
| hsa_PTK2_0022100 | Exon-Exon | chr8:141762331-141771361 | chr8:140752232-140761262 | 91 nt | 0.4396 |
| hsa_PTK2_0021900 | Exon-Exon | chr8:141762331-141772487 | chr8:140752232-140762388 | 204 nt | 0.3922 |
| hsa_PTK2_0022300 | Exon-Exon | chr8:141762331-141780898 | chr8:140752232-140770799 | 226 nt | 0.4204 |
| hsa_PTK2_0022400 | Exon-Exon | chr8:141762331-141799625 | chr8:140752232-140789526 | 204 nt | 0.3922 |
| hsa_PTK2_0022500 | Exon-Exon | chr8:141762331-141803483 | chr8:140752232-140793384 | 147 nt | 0.4626 |
| hsa_PTK2_0022600 | Exon-Exon | chr8:141762331-141813749 | chr8:140752232-140803650 | 85 nt | 0.4118 |
| hsa_PTK2_0022700 | Exon-Exon | chr8:141762331-141828453 | chr8:140752232-140818354 | 667 nt | 0.4453 |
Showing 291 to 300 of 573 entries
Forensic Context
A study in mice demonstrated that the circPTK2 is induced after oxygen-glucose deprivation and regulates microglia-induced hippocampal neuronal apoptosis via the miR-29b/SOCS-1-JAK2/STAT3-IL-1β axis [Huang et al. DOI:10.3390/cells11091381]. In a separate review, the circPTK2 was similarly noted to be induced after stroke, where it suppresses miR-29b, leading to JAK2/STAT3 activation, IL-1β production, and neuronal apoptosis [Mehta et al. DOI:10.1016/j.pneurobio.2020.101746].