Basic Information
Symbol
circPTK2
RNA Class
circRNA
Alias
Protein Tyrosine Kinase 2
PPP1R71
FAK1
FAK
FADK
Protein Phosphatase 1 Regulatory Subunit 71
Focal Adhesion Kinase-Related Nonkinase
PTK2 Protein Tyrosine Kinase 2
Focal Adhesion Kinase 1
EC 2.7.10.2
Pp125FAK
P125FAK
FADK 1
FRNK
Protein Phosphatase 1, Regulatory Subunit 71
FAK-Related Non-Kinase Polypeptide
Protein-Tyrosine Kinase 2
EC 2.7.10
Location (GRCh37)
8:141668481-142005154
UCSC Genome Browser
Location (GRCh38)
8:140658382-140995055
Host gene
PTK2
Host category
mRNA
Forensic tag(s)
Sudden death from CNS diseases
External database
Transcripts
| ID | Type | Location (GRCh37) | Location (GRCh38) | Length | GC content |
|---|---|---|---|---|---|
| hsa_PTK2_0022800 | Exon-Exon | chr8:141762331-141829119 | chr8:140752232-140819020 | 91 nt | 0.4176 |
| hsa_PTK2_0022900 | Exon-Exon | chr8:141762331-141856421 | chr8:140752232-140846322 | 301 nt | 0.3920 |
| hsa_PTK2_0023000 | Exon-Exon | chr8:141762331-141856777 | chr8:140752232-140846678 | 354 nt | 0.3898 |
| hsa_PTK2_0023100 | Exon-Exon | chr8:141762331-141874498 | chr8:140752232-140864399 | 253 nt | 0.3715 |
| hsa_PTK2_0023200 | Exon-Exon | chr8:141762331-141889736 | chr8:140752232-140879637 | 332 nt | 0.4428 |
| hsa_PTK2_0023300 | Exon-Exon | chr8:141762331-141900702 | chr8:140752232-140890603 | 146 nt | 0.4521 |
| hsa_PTK2_0022000 | Exon-Exon | chr8:141762331-141931231 | chr8:140752232-140921132 | 1768 nt | 0.4367 |
| hsa_PTK2_0023400 | Exon-Exon | chr8:141762331-141935848 | chr8:140752232-140925749 | 89 nt | 0.5169 |
| hsa_PTK2_0021600 | Intron-Exon-Intron | chr8:141762331-141941162 | chr8:140752232-140931063 | 250 nt | 0.3880 |
| hsa_PTK2_0021700 | Intron-Exon-Intron | chr8:141762331-141944153 | chr8:140752232-140934054 | 250 nt | 0.2760 |
Showing 301 to 310 of 573 entries
Forensic Context
A study in mice demonstrated that the circPTK2 is induced after oxygen-glucose deprivation and regulates microglia-induced hippocampal neuronal apoptosis via the miR-29b/SOCS-1-JAK2/STAT3-IL-1β axis [Huang et al. DOI:10.3390/cells11091381]. In a separate review, the circPTK2 was similarly noted to be induced after stroke, where it suppresses miR-29b, leading to JAK2/STAT3 activation, IL-1β production, and neuronal apoptosis [Mehta et al. DOI:10.1016/j.pneurobio.2020.101746].