Basic Information

Symbol
circPTK2
RNA Class
circRNA
Alias
Protein Tyrosine Kinase 2 PPP1R71 FAK1 FAK FADK Protein Phosphatase 1 Regulatory Subunit 71 Focal Adhesion Kinase-Related Nonkinase PTK2 Protein Tyrosine Kinase 2 Focal Adhesion Kinase 1 EC 2.7.10.2 Pp125FAK P125FAK FADK 1 FRNK Protein Phosphatase 1, Regulatory Subunit 71 FAK-Related Non-Kinase Polypeptide Protein-Tyrosine Kinase 2 EC 2.7.10
Location (GRCh37)
8:141668481-142005154 UCSC Genome Browser
Location (GRCh38)
8:140658382-140995055
UCSC Genome Browser Search in Marker Scope
Host gene
PTK2
Host category
mRNA
Forensic tag(s)
Sudden death from CNS diseases
External database
circbank

Transcripts

ID Type Location (GRCh37) Location (GRCh38) Length GC content
hsa_PTK2_0021800 Intron-Exon-Intron chr8:141762331-141958822 chr8:140752232-140948723 250 nt 0.3160
hsa_PTK2_0024400 Intron-Exon-Intron chr8:141771264-141774985 chr8:140761165-140764886 122 nt 0.3279
hsa_PTK2_0024500 Intron-Exon-Intron chr8:141771264-141776986 chr8:140761165-140766887 233 nt 0.3991
hsa_PTK2_0024600 Exon-Exon chr8:141771264-141779691 chr8:140761165-140769592 104 nt 0.3750
hsa_PTK2_0024800 Intron-Exon-Intron chr8:141771264-141782584 chr8:140761165-140772485 104 nt 0.4038
hsa_PTK2_0024900 Intron-Exon-Intron chr8:141771264-141784729 chr8:140761165-140774630 104 nt 0.3846
hsa_PTK2_0025000 Intron-Exon-Intron chr8:141771264-141790555 chr8:140761165-140780456 155 nt 0.3742
hsa_PTK2_0024200 Intron-Exon-Intron chr8:141771264-141851032 chr8:140761165-140840933 250 nt 0.2960
hsa_PTK2_0025200 Exon-Exon chr8:141771264-141856777 chr8:140761165-140846678 241 nt 0.4025
hsa_PTK2_0025300 Exon-Exon chr8:141771264-141874498 chr8:140761165-140864399 262 nt 0.3588
Showing 311 to 320 of 573 entries
Forensic Context

A study in mice demonstrated that the circPTK2 is induced after oxygen-glucose deprivation and regulates microglia-induced hippocampal neuronal apoptosis via the miR-29b/SOCS-1-JAK2/STAT3-IL-1β axis [Huang et al. DOI:10.3390/cells11091381]. In a separate review, the circPTK2 was similarly noted to be induced after stroke, where it suppresses miR-29b, leading to JAK2/STAT3 activation, IL-1β production, and neuronal apoptosis [Mehta et al. DOI:10.1016/j.pneurobio.2020.101746].