Basic Information

Symbol
circPTK2
RNA Class
circRNA
Alias
Protein Tyrosine Kinase 2 PPP1R71 FAK1 FAK FADK Protein Phosphatase 1 Regulatory Subunit 71 Focal Adhesion Kinase-Related Nonkinase PTK2 Protein Tyrosine Kinase 2 Focal Adhesion Kinase 1 EC 2.7.10.2 Pp125FAK P125FAK FADK 1 FRNK Protein Phosphatase 1, Regulatory Subunit 71 FAK-Related Non-Kinase Polypeptide Protein-Tyrosine Kinase 2 EC 2.7.10
Location (GRCh37)
8:141668481-142005154 UCSC Genome Browser
Location (GRCh38)
8:140658382-140995055
UCSC Genome Browser Search in Marker Scope
Host gene
PTK2
Host category
mRNA
Forensic tag(s)
Sudden death from CNS diseases
External database
circbank

Transcripts

ID Type Location (GRCh37) Location (GRCh38) Length GC content
hsa_PTK2_0026300 Exon-Exon chr8:141774333-141856421 chr8:140764234-140846322 151 nt 0.4040
hsa_PTK2_0026400 Exon-Exon chr8:141774333-141856777 chr8:140764234-140846678 57 nt 0.3509
hsa_PTK2_0026500 Exon-Exon chr8:141774333-141874498 chr8:140764234-140864399 890 nt 0.4180
hsa_PTK2_0026600 Intron-Exon-Intron chr8:141774333-141884629 chr8:140764234-140874530 53 nt 0.5849
hsa_PTK2_0026700 Exon-Exon chr8:141774333-141900868 chr8:140764234-140890769 116 nt 0.4483
hsa_chr8_0162700 Intergenic-Intergenic chr8:141774422-141775027 chr8:140764323-140764928 606 nt 0.3383
hsa_chr8_0162800 Intergenic-Intergenic chr8:141775290-141775429 chr8:140765191-140765330 140 nt 0.3786
hsa_PTK2_0026900 Intron-Exon-Intron chr8:141779674-141840625 chr8:140769575-140830526 55 nt 0.3273
hsa_PTK2_0027000 Intron-Exon-Intron chr8:141779674-141874498 chr8:140769575-140864399 88 nt 0.3068
hsa_PTK2_0027100 Intron-Exon-Intron chr8:141779674-141900868 chr8:140769575-140890769 149 nt 0.4966
Showing 331 to 340 of 573 entries
Forensic Context

A study in mice demonstrated that the circPTK2 is induced after oxygen-glucose deprivation and regulates microglia-induced hippocampal neuronal apoptosis via the miR-29b/SOCS-1-JAK2/STAT3-IL-1β axis [Huang et al. DOI:10.3390/cells11091381]. In a separate review, the circPTK2 was similarly noted to be induced after stroke, where it suppresses miR-29b, leading to JAK2/STAT3 activation, IL-1β production, and neuronal apoptosis [Mehta et al. DOI:10.1016/j.pneurobio.2020.101746].