Basic Information

Symbol
circPTK2
RNA Class
circRNA
Alias
Protein Tyrosine Kinase 2 PPP1R71 FAK1 FAK FADK Protein Phosphatase 1 Regulatory Subunit 71 Focal Adhesion Kinase-Related Nonkinase PTK2 Protein Tyrosine Kinase 2 Focal Adhesion Kinase 1 EC 2.7.10.2 Pp125FAK P125FAK FADK 1 FRNK Protein Phosphatase 1, Regulatory Subunit 71 FAK-Related Non-Kinase Polypeptide Protein-Tyrosine Kinase 2 EC 2.7.10
Location (GRCh37)
8:141668481-142005154 UCSC Genome Browser
Location (GRCh38)
8:140658382-140995055
UCSC Genome Browser Search in Marker Scope
Host gene
PTK2
Host category
mRNA
Forensic tag(s)
Sudden death from CNS diseases
External database
circbank

Transcripts

ID Type Location (GRCh37) Location (GRCh38) Length GC content
hsa_PTK2_0026800 Intron-Exon-Intron chr8:141779674-141935848 chr8:140769575-140925749 250 nt 0.4080
hsa_PTK2_0027200 Intron-Exon-Intron chr8:141782403-141900868 chr8:140772304-140890769 227 nt 0.4405
hsa_PTK2_0027400 Intron-Exon-Intron chr8:141784505-141829119 chr8:140774406-140819020 219 nt 0.4018
hsa_PTK2_0027300 Intron-Exon-Intron chr8:141784505-141900868 chr8:140774406-140890769 250 nt 0.3840
hsa_chr8_0162900 Intergenic-Intergenic chr8:141788384-141788947 chr8:140778285-140778848 564 nt 0.4592
hsa_PTK2_0027500 Intron-Exon-Intron chr8:141789930-141813749 chr8:140779831-140803650 250 nt 0.3520
hsa_PTK2_0027700 Intron-Exon-Intron chr8:141789930-141840625 chr8:140779831-140830526 86 nt 0.3721
hsa_PTK2_0027800 Intron-Exon-Intron chr8:141789930-141874498 chr8:140779831-140864399 88 nt 0.3068
hsa_PTK2_0027600 Intron-Exon-Intron chr8:141789930-141889736 chr8:140779831-140879637 250 nt 0.3960
hsa_PTK2_0027900 Intron-Exon-Intron chr8:141789930-141900868 chr8:140779831-140890769 227 nt 0.4405
Showing 341 to 350 of 573 entries
Forensic Context

A study in mice demonstrated that the circPTK2 is induced after oxygen-glucose deprivation and regulates microglia-induced hippocampal neuronal apoptosis via the miR-29b/SOCS-1-JAK2/STAT3-IL-1β axis [Huang et al. DOI:10.3390/cells11091381]. In a separate review, the circPTK2 was similarly noted to be induced after stroke, where it suppresses miR-29b, leading to JAK2/STAT3 activation, IL-1β production, and neuronal apoptosis [Mehta et al. DOI:10.1016/j.pneurobio.2020.101746].