Basic Information

Symbol
circPTK2
RNA Class
circRNA
Alias
Protein Tyrosine Kinase 2 PPP1R71 FAK1 FAK FADK Protein Phosphatase 1 Regulatory Subunit 71 Focal Adhesion Kinase-Related Nonkinase PTK2 Protein Tyrosine Kinase 2 Focal Adhesion Kinase 1 EC 2.7.10.2 Pp125FAK P125FAK FADK 1 FRNK Protein Phosphatase 1, Regulatory Subunit 71 FAK-Related Non-Kinase Polypeptide Protein-Tyrosine Kinase 2 EC 2.7.10
Location (GRCh37)
8:141668481-142005154 UCSC Genome Browser
Location (GRCh38)
8:140658382-140995055
UCSC Genome Browser Search in Marker Scope
Host gene
PTK2
Host category
mRNA
Forensic tag(s)
Sudden death from CNS diseases
External database
circbank

Transcripts

ID Type Location (GRCh37) Location (GRCh38) Length GC content
hsa_PTK2_0028000 Intron-Exon-Intron chr8:141794187-141801395 chr8:140784088-140791296 250 nt 0.4160
hsa_PTK2_0028100 Intron-Intron chr8:141794749-141794939 chr8:140784650-140784840 191 nt 0.3298
hsa_PTK2_0028300 Intron-Exon-Intron chr8:141798263-141829119 chr8:140788164-140819020 219 nt 0.4018
hsa_PTK2_0028400 Intron-Exon-Intron chr8:141798263-141840625 chr8:140788164-140830526 61 nt 0.3443
hsa_PTK2_0028200 Intron-Exon-Intron chr8:141798263-141856777 chr8:140788164-140846678 2037 nt 0.3957
hsa_PTK2_0028500 Intron-Exon-Intron chr8:141798263-141874498 chr8:140788164-140864399 292 nt 0.4315
hsa_PTK2_0028600 Intron-Exon-Intron chr8:141798263-141889736 chr8:140788164-140879637 255 nt 0.4549
hsa_PTK2_0028700 Intron-Exon-Intron chr8:141798263-141900868 chr8:140788164-140890769 374 nt 0.4305
hsa_PTK2_0028800 Intron-Exon chr8:141798263-141931231 chr8:140788164-140921132 147 nt 0.4150
hsa_PTK2_0028900 Intron-Exon-Intron chr8:141798395-141829119 chr8:140788296-140819020 31 nt 0.4516
Showing 351 to 360 of 573 entries
Forensic Context

A study in mice demonstrated that the circPTK2 is induced after oxygen-glucose deprivation and regulates microglia-induced hippocampal neuronal apoptosis via the miR-29b/SOCS-1-JAK2/STAT3-IL-1β axis [Huang et al. DOI:10.3390/cells11091381]. In a separate review, the circPTK2 was similarly noted to be induced after stroke, where it suppresses miR-29b, leading to JAK2/STAT3 activation, IL-1β production, and neuronal apoptosis [Mehta et al. DOI:10.1016/j.pneurobio.2020.101746].