Basic Information

Symbol
circPTK2
RNA Class
circRNA
Alias
Protein Tyrosine Kinase 2 PPP1R71 FAK1 FAK FADK Protein Phosphatase 1 Regulatory Subunit 71 Focal Adhesion Kinase-Related Nonkinase PTK2 Protein Tyrosine Kinase 2 Focal Adhesion Kinase 1 EC 2.7.10.2 Pp125FAK P125FAK FADK 1 FRNK Protein Phosphatase 1, Regulatory Subunit 71 FAK-Related Non-Kinase Polypeptide Protein-Tyrosine Kinase 2 EC 2.7.10
Location (GRCh37)
8:141668481-142005154 UCSC Genome Browser
Location (GRCh38)
8:140658382-140995055
UCSC Genome Browser Search in Marker Scope
Host gene
PTK2
Host category
mRNA
Forensic tag(s)
Sudden death from CNS diseases
External database
circbank

Transcripts

ID Type Location (GRCh37) Location (GRCh38) Length GC content
hsa_PTK2_0031100 Intron-Exon-Intron chr8:141799573-141922340 chr8:140789474-140912241 84 nt 0.5357
hsa_PTK2_0030000 Intron-Exon-Intron chr8:141799573-141922566 chr8:140789474-140912467 250 nt 0.4240
hsa_PTK2_0030200 Exon-Exon chr8:141799573-141931022 chr8:140789474-140920923 1319 nt 0.4458
hsa_PTK2_0031300 Exon-Exon chr8:141799573-141931315 chr8:140789474-140921216 456 nt 0.4737
hsa_PTK2_0031400 Intron-Exon-Intron chr8:141799573-141941162 chr8:140789474-140931063 84 nt 0.5357
hsa_PTK2_0031500 Intron-Exon-Intron chr8:141799573-141958822 chr8:140789474-140948723 58 nt 0.5000
hsa_PTK2_0031600 Exon-Exon chr8:141799573-141994254 chr8:140789474-140984155 53 nt 0.5849
hsa_PTK2_0032400 Exon-Exon chr8:141803453-141840625 chr8:140793354-140830526 526 nt 0.4278
hsa_PTK2_0032500 Exon-Exon chr8:141803453-141856421 chr8:140793354-140846322 202 nt 0.4356
hsa_PTK2_0032600 Exon-Exon chr8:141803453-141856777 chr8:140793354-140846678 149 nt 0.4966
Showing 371 to 380 of 573 entries
Forensic Context

A study in mice demonstrated that the circPTK2 is induced after oxygen-glucose deprivation and regulates microglia-induced hippocampal neuronal apoptosis via the miR-29b/SOCS-1-JAK2/STAT3-IL-1β axis [Huang et al. DOI:10.3390/cells11091381]. In a separate review, the circPTK2 was similarly noted to be induced after stroke, where it suppresses miR-29b, leading to JAK2/STAT3 activation, IL-1β production, and neuronal apoptosis [Mehta et al. DOI:10.1016/j.pneurobio.2020.101746].