Basic Information

Symbol
circPTK2
RNA Class
circRNA
Alias
Protein Tyrosine Kinase 2 PPP1R71 FAK1 FAK FADK Protein Phosphatase 1 Regulatory Subunit 71 Focal Adhesion Kinase-Related Nonkinase PTK2 Protein Tyrosine Kinase 2 Focal Adhesion Kinase 1 EC 2.7.10.2 Pp125FAK P125FAK FADK 1 FRNK Protein Phosphatase 1, Regulatory Subunit 71 FAK-Related Non-Kinase Polypeptide Protein-Tyrosine Kinase 2 EC 2.7.10
Location (GRCh37)
8:141668481-142005154 UCSC Genome Browser
Location (GRCh38)
8:140658382-140995055
UCSC Genome Browser Search in Marker Scope
Host gene
PTK2
Host category
mRNA
Forensic tag(s)
Sudden death from CNS diseases
External database
circbank

Transcripts

ID Type Location (GRCh37) Location (GRCh38) Length GC content
hsa_PTK2_0032700 Intron-Exon-Intron chr8:141803453-141884629 chr8:140793354-140874530 31 nt 0.4516
hsa_PTK2_0032200 Intron-Exon-Intron chr8:141803453-141922566 chr8:140793354-140912467 250 nt 0.4040
hsa_PTK2_0032800 Exon-Exon chr8:141803453-141931231 chr8:140793354-140921132 37 nt 0.4595
hsa_PTK2_0032900 Exon-Exon chr8:141803453-141935848 chr8:140793354-140925749 31 nt 0.4516
hsa_PTK2_0032300 Intron-Exon-Intron chr8:141803453-141958822 chr8:140793354-140948723 250 nt 0.3480
hsa_PTK2_0033000 Intron-Intron chr8:141804782-141804987 chr8:140794683-140794888 206 nt 0.4612
hsa_PTK2_0033200 Intron-Exon-Intron chr8:141810553-141874498 chr8:140800454-140864399 88 nt 0.3068
hsa_PTK2_0034000 Exon-Exon chr8:141810558-141828410 chr8:140800459-140818311 261 nt 0.4713
hsa_PTK2_0034300 Exon-Exon chr8:141810558-141829051 chr8:140800459-140818952 372 nt 0.4570
hsa_PTK2_0034400 Intron-Exon-Intron chr8:141810558-141846527 chr8:140800459-140836428 294 nt 0.4524
Showing 381 to 390 of 573 entries
Forensic Context

A study in mice demonstrated that the circPTK2 is induced after oxygen-glucose deprivation and regulates microglia-induced hippocampal neuronal apoptosis via the miR-29b/SOCS-1-JAK2/STAT3-IL-1β axis [Huang et al. DOI:10.3390/cells11091381]. In a separate review, the circPTK2 was similarly noted to be induced after stroke, where it suppresses miR-29b, leading to JAK2/STAT3 activation, IL-1β production, and neuronal apoptosis [Mehta et al. DOI:10.1016/j.pneurobio.2020.101746].