Basic Information
Symbol
circPTK2
RNA Class
circRNA
Alias
Protein Tyrosine Kinase 2
PPP1R71
FAK1
FAK
FADK
Protein Phosphatase 1 Regulatory Subunit 71
Focal Adhesion Kinase-Related Nonkinase
PTK2 Protein Tyrosine Kinase 2
Focal Adhesion Kinase 1
EC 2.7.10.2
Pp125FAK
P125FAK
FADK 1
FRNK
Protein Phosphatase 1, Regulatory Subunit 71
FAK-Related Non-Kinase Polypeptide
Protein-Tyrosine Kinase 2
EC 2.7.10
Location (GRCh37)
8:141668481-142005154
UCSC Genome Browser
Location (GRCh38)
8:140658382-140995055
Host gene
PTK2
Host category
mRNA
Forensic tag(s)
Sudden death from CNS diseases
External database
Transcripts
| ID | Type | Location (GRCh37) | Location (GRCh38) | Length | GC content |
|---|---|---|---|---|---|
| hsa_PTK2_0011200 | Exon-Exon | chr8:141727697-141829119 | chr8:140717598-140819020 | 1494 nt | 0.4418 |
| hsa_PTK2_0012800 | Exon-Exon | chr8:141745350-141749206 | chr8:140735251-140739107 | 295 nt | 0.4508 |
| hsa_PTK2_0012900 | Exon-Exon | chr8:141745350-141762415 | chr8:140735251-140752316 | 698 nt | 0.4255 |
| hsa_PTK2_0013700 | Exon-Exon | chr8:141745350-141774389 | chr8:140735251-140764290 | 874 nt | 0.4142 |
| hsa_PTK2_0015300 | Exon-Exon | chr8:141749117-141754866 | chr8:140739018-140744767 | 307 nt | 0.3909 |
| hsa_PTK2_0015400 | Exon-Exon | chr8:141749117-141756959 | chr8:140739018-140746860 | 408 nt | 0.4044 |
| hsa_PTK2_0015500 | Exon-Exon | chr8:141749117-141762415 | chr8:140739018-140752316 | 493 nt | 0.4057 |
| hsa_PTK2_0015600 | Exon-Exon | chr8:141749117-141810675 | chr8:140739018-140800576 | 850 nt | 0.4271 |
| hsa_PTK2_0015700 | Exon-Exon | chr8:141749117-141829119 | chr8:140739018-140819020 | 1177 nt | 0.4231 |
| hsa_PTK2_0015800 | Exon-Exon | chr8:141749117-141889736 | chr8:140739018-140879637 | 1630 nt | 0.4239 |
Showing 31 to 40 of 573 entries
Forensic Context
A study in mice demonstrated that the circPTK2 is induced after oxygen-glucose deprivation and regulates microglia-induced hippocampal neuronal apoptosis via the miR-29b/SOCS-1-JAK2/STAT3-IL-1β axis [Huang et al. DOI:10.3390/cells11091381]. In a separate review, the circPTK2 was similarly noted to be induced after stroke, where it suppresses miR-29b, leading to JAK2/STAT3 activation, IL-1β production, and neuronal apoptosis [Mehta et al. DOI:10.1016/j.pneurobio.2020.101746].