Basic Information

Symbol
circPTK2
RNA Class
circRNA
Alias
Protein Tyrosine Kinase 2 PPP1R71 FAK1 FAK FADK Protein Phosphatase 1 Regulatory Subunit 71 Focal Adhesion Kinase-Related Nonkinase PTK2 Protein Tyrosine Kinase 2 Focal Adhesion Kinase 1 EC 2.7.10.2 Pp125FAK P125FAK FADK 1 FRNK Protein Phosphatase 1, Regulatory Subunit 71 FAK-Related Non-Kinase Polypeptide Protein-Tyrosine Kinase 2 EC 2.7.10
Location (GRCh37)
8:141668481-142005154 UCSC Genome Browser
Location (GRCh38)
8:140658382-140995055
UCSC Genome Browser Search in Marker Scope
Host gene
PTK2
Host category
mRNA
Forensic tag(s)
Sudden death from CNS diseases
External database
circbank

Transcripts

ID Type Location (GRCh37) Location (GRCh38) Length GC content
hsa_PTK2_0034100 Exon-Exon chr8:141810558-141856421 chr8:140800459-140846322 563 nt 0.4263
hsa_PTK2_0034500 Intron-Exon-Intron chr8:141810558-141857700 chr8:140800459-140847601 72 nt 0.4583
hsa_PTK2_0034200 Exon-Exon chr8:141810558-141900867 chr8:140800459-140890768 1124 nt 0.4342
hsa_PTK2_0034600 Exon-Exon chr8:141810558-141931231 chr8:140800459-140921132 118 nt 0.5085
hsa_PTK2_0034700 Exon-Exon chr8:141810558-141935848 chr8:140800459-140925749 95 nt 0.5053
hsa_PTK2_0034800 Intron-Exon-Intron chr8:141810558-141958822 chr8:140800459-140948723 58 nt 0.5000
hsa_PTK2_0034900 Intron-Exon-Intron chr8:141810558-141964946 chr8:140800459-140954847 118 nt 0.5085
hsa_PTK2_0035000 Exon-Exon chr8:141810601-141874437 chr8:140800502-140864338 627 nt 0.4179
hsa_PTK2_0035300 Intron-Exon-Intron chr8:141813642-141837196 chr8:140803543-140827097 227 nt 0.4185
hsa_PTK2_0035400 Exon-Exon chr8:141813642-141840625 chr8:140803543-140830526 163 nt 0.3988
Showing 391 to 400 of 573 entries
Forensic Context

A study in mice demonstrated that the circPTK2 is induced after oxygen-glucose deprivation and regulates microglia-induced hippocampal neuronal apoptosis via the miR-29b/SOCS-1-JAK2/STAT3-IL-1β axis [Huang et al. DOI:10.3390/cells11091381]. In a separate review, the circPTK2 was similarly noted to be induced after stroke, where it suppresses miR-29b, leading to JAK2/STAT3 activation, IL-1β production, and neuronal apoptosis [Mehta et al. DOI:10.1016/j.pneurobio.2020.101746].