Basic Information

Symbol
circPTK2
RNA Class
circRNA
Alias
Protein Tyrosine Kinase 2 PPP1R71 FAK1 FAK FADK Protein Phosphatase 1 Regulatory Subunit 71 Focal Adhesion Kinase-Related Nonkinase PTK2 Protein Tyrosine Kinase 2 Focal Adhesion Kinase 1 EC 2.7.10.2 Pp125FAK P125FAK FADK 1 FRNK Protein Phosphatase 1, Regulatory Subunit 71 FAK-Related Non-Kinase Polypeptide Protein-Tyrosine Kinase 2 EC 2.7.10
Location (GRCh37)
8:141668481-142005154 UCSC Genome Browser
Location (GRCh38)
8:140658382-140995055
UCSC Genome Browser Search in Marker Scope
Host gene
PTK2
Host category
mRNA
Forensic tag(s)
Sudden death from CNS diseases
External database
circbank

Transcripts

ID Type Location (GRCh37) Location (GRCh38) Length GC content
hsa_PTK2_0037900 Intron-Exon-Intron chr8:141828376-141856806 chr8:140818277-140846707 391 nt 0.4015
hsa_PTK2_0038000 Intron-Exon-Intron chr8:141828376-141861954 chr8:140818277-140851855 202 nt 0.4158
hsa_PTK2_0038100 Intron-Exon-Intron chr8:141828376-141866992 chr8:140818277-140856893 188 nt 0.3989
hsa_PTK2_0038200 Exon-Exon chr8:141828376-141900702 chr8:140818277-140890603 141 nt 0.4468
hsa_PTK2_0038300 Exon-Exon chr8:141828376-141900867 chr8:140818277-140890768 240 nt 0.5167
hsa_PTK2_0037000 Intron-Exon-Intron chr8:141828376-141903402 chr8:140818277-140893303 250 nt 0.4120
hsa_PTK2_0038400 Intron-Exon-Intron chr8:141828376-141919720 chr8:140818277-140909621 80 nt 0.4000
hsa_PTK2_0037100 Intron-Exon-Intron chr8:141828376-141920090 chr8:140818277-140909991 250 nt 0.3040
hsa_PTK2_0038500 Intron-Exon-Intron chr8:141828376-141922340 chr8:140818277-140912241 197 nt 0.4975
hsa_PTK2_0037200 Intron-Exon-Intron chr8:141828376-141922566 chr8:140818277-140912467 250 nt 0.4040
Showing 411 to 420 of 573 entries
Forensic Context

A study in mice demonstrated that the circPTK2 is induced after oxygen-glucose deprivation and regulates microglia-induced hippocampal neuronal apoptosis via the miR-29b/SOCS-1-JAK2/STAT3-IL-1β axis [Huang et al. DOI:10.3390/cells11091381]. In a separate review, the circPTK2 was similarly noted to be induced after stroke, where it suppresses miR-29b, leading to JAK2/STAT3 activation, IL-1β production, and neuronal apoptosis [Mehta et al. DOI:10.1016/j.pneurobio.2020.101746].