Basic Information

Symbol
circPTK2
RNA Class
circRNA
Alias
Protein Tyrosine Kinase 2 PPP1R71 FAK1 FAK FADK Protein Phosphatase 1 Regulatory Subunit 71 Focal Adhesion Kinase-Related Nonkinase PTK2 Protein Tyrosine Kinase 2 Focal Adhesion Kinase 1 EC 2.7.10.2 Pp125FAK P125FAK FADK 1 FRNK Protein Phosphatase 1, Regulatory Subunit 71 FAK-Related Non-Kinase Polypeptide Protein-Tyrosine Kinase 2 EC 2.7.10
Location (GRCh37)
8:141668481-142005154 UCSC Genome Browser
Location (GRCh38)
8:140658382-140995055
UCSC Genome Browser Search in Marker Scope
Host gene
PTK2
Host category
mRNA
Forensic tag(s)
Sudden death from CNS diseases
External database
circbank

Transcripts

ID Type Location (GRCh37) Location (GRCh38) Length GC content
hsa_PTK2_0037600 Exon-Exon chr8:141828376-141931022 chr8:140818277-140920923 1009 nt 0.4321
hsa_PTK2_0038600 Exon-Exon chr8:141828376-141931231 chr8:140818277-140921132 84 nt 0.4762
hsa_PTK2_0037300 Intron-Exon-Intron chr8:141828376-141937513 chr8:140818277-140927414 2653 nt 0.3811
hsa_PTK2_0037400 Intron-Exon-Intron chr8:141828376-141958822 chr8:140818277-140948723 250 nt 0.3480
hsa_PTK2_0038700 Intron-Exon-Intron chr8:141828376-141964946 chr8:140818277-140954847 78 nt 0.4744
hsa_PTK2_0037500 Intron-Exon-Intron chr8:141828376-141993741 chr8:140818277-140983642 250 nt 0.3640
hsa_PTK2_0038900 Exon-Exon chr8:141828979-141856421 chr8:140818880-140846322 141 nt 0.3617
hsa_PTK2_0039000 Exon-Exon chr8:141828979-141874498 chr8:140818880-140864399 229 nt 0.3406
hsa_PTK2_0039100 Exon-Exon chr8:141828979-141889736 chr8:140818880-140879637 204 nt 0.3824
hsa_PTK2_0039200 Exon-Exon chr8:141828979-141900868 chr8:140818880-140890769 196 nt 0.3520
Showing 421 to 430 of 573 entries
Forensic Context

A study in mice demonstrated that the circPTK2 is induced after oxygen-glucose deprivation and regulates microglia-induced hippocampal neuronal apoptosis via the miR-29b/SOCS-1-JAK2/STAT3-IL-1β axis [Huang et al. DOI:10.3390/cells11091381]. In a separate review, the circPTK2 was similarly noted to be induced after stroke, where it suppresses miR-29b, leading to JAK2/STAT3 activation, IL-1β production, and neuronal apoptosis [Mehta et al. DOI:10.1016/j.pneurobio.2020.101746].