Basic Information

Symbol
circPTK2
RNA Class
circRNA
Alias
Protein Tyrosine Kinase 2 PPP1R71 FAK1 FAK FADK Protein Phosphatase 1 Regulatory Subunit 71 Focal Adhesion Kinase-Related Nonkinase PTK2 Protein Tyrosine Kinase 2 Focal Adhesion Kinase 1 EC 2.7.10.2 Pp125FAK P125FAK FADK 1 FRNK Protein Phosphatase 1, Regulatory Subunit 71 FAK-Related Non-Kinase Polypeptide Protein-Tyrosine Kinase 2 EC 2.7.10
Location (GRCh37)
8:141668481-142005154 UCSC Genome Browser
Location (GRCh38)
8:140658382-140995055
UCSC Genome Browser Search in Marker Scope
Host gene
PTK2
Host category
mRNA
Forensic tag(s)
Sudden death from CNS diseases
External database
circbank

Transcripts

ID Type Location (GRCh37) Location (GRCh38) Length GC content
hsa_PTK2_0039300 Exon-Exon chr8:141828981-141889649 chr8:140818882-140879550 80 nt 0.4000
hsa_chr8_0163000 Intergenic-Intergenic chr8:141829069-141874432 chr8:140818970-140864333 271 nt 0.3727
hsa_PTK2_0039400 Intron-Exon-Intron chr8:141831638-141900868 chr8:140821539-140890769 188 nt 0.4149
hsa_PTK2_0039500 Intron-Exon-Intron chr8:141836676-141900868 chr8:140826577-140890769 369 nt 0.4309
hsa_PTK2_0039700 Intron-Exon-Intron chr8:141837078-141840625 chr8:140826979-140830526 174 nt 0.3793
hsa_PTK2_0039800 Intron-Exon-Intron chr8:141837078-141856777 chr8:140826979-140846678 317 nt 0.3943
hsa_PTK2_0039900 Intron-Exon-Intron chr8:141837078-141889736 chr8:140826979-140879637 174 nt 0.3793
hsa_PTK2_0040000 Intron-Exon-Intron chr8:141837078-141900868 chr8:140826979-140890769 317 nt 0.3943
hsa_PTK2_0040100 Intron-Exon-Intron chr8:141838141-141874498 chr8:140828042-140864399 2716 nt 0.3991
hsa_PTK2_0040200 Intron-Intron chr8:141840151-141840292 chr8:140830052-140830193 142 nt 0.3803
Showing 431 to 440 of 573 entries
Forensic Context

A study in mice demonstrated that the circPTK2 is induced after oxygen-glucose deprivation and regulates microglia-induced hippocampal neuronal apoptosis via the miR-29b/SOCS-1-JAK2/STAT3-IL-1β axis [Huang et al. DOI:10.3390/cells11091381]. In a separate review, the circPTK2 was similarly noted to be induced after stroke, where it suppresses miR-29b, leading to JAK2/STAT3 activation, IL-1β production, and neuronal apoptosis [Mehta et al. DOI:10.1016/j.pneurobio.2020.101746].