Basic Information

Symbol
circPTK2
RNA Class
circRNA
Alias
Protein Tyrosine Kinase 2 PPP1R71 FAK1 FAK FADK Protein Phosphatase 1 Regulatory Subunit 71 Focal Adhesion Kinase-Related Nonkinase PTK2 Protein Tyrosine Kinase 2 Focal Adhesion Kinase 1 EC 2.7.10.2 Pp125FAK P125FAK FADK 1 FRNK Protein Phosphatase 1, Regulatory Subunit 71 FAK-Related Non-Kinase Polypeptide Protein-Tyrosine Kinase 2 EC 2.7.10
Location (GRCh37)
8:141668481-142005154 UCSC Genome Browser
Location (GRCh38)
8:140658382-140995055
UCSC Genome Browser Search in Marker Scope
Host gene
PTK2
Host category
mRNA
Forensic tag(s)
Sudden death from CNS diseases
External database
circbank

Transcripts

ID Type Location (GRCh37) Location (GRCh38) Length GC content
hsa_PTK2_0040900 Exon-Exon chr8:141840571-141856777 chr8:140830472-140846678 198 nt 0.3889
hsa_PTK2_0041000 Intron-Exon-Intron chr8:141840571-141857700 chr8:140830472-140847601 118 nt 0.3814
hsa_PTK2_0040600 Intron-Exon-Intron chr8:141840571-141884629 chr8:140830472-140874530 250 nt 0.3080
hsa_PTK2_0041100 Exon-Exon chr8:141840571-141900702 chr8:140830472-140890603 61 nt 0.5082
hsa_PTK2_0041300 Intron-Exon-Intron chr8:141840571-141903402 chr8:140830472-140893303 118 nt 0.3814
hsa_PTK2_0040700 Intron-Exon-Intron chr8:141840571-141922566 chr8:140830472-140912467 250 nt 0.3640
hsa_PTK2_0041400 Exon-Exon chr8:141840571-141931231 chr8:140830472-140921132 61 nt 0.3443
hsa_PTK2_0040800 Intron-Exon-Intron chr8:141840571-141958822 chr8:140830472-140948723 250 nt 0.3040
hsa_PTK2_0041500 Intron-Exon-Intron chr8:141840571-141993741 chr8:140830472-140983642 61 nt 0.3443
hsa_chr8_0163200 Intergenic-Intergenic chr8:141842408-141847614 chr8:140832309-140837515 250 nt 0.4000
Showing 441 to 450 of 573 entries
Forensic Context

A study in mice demonstrated that the circPTK2 is induced after oxygen-glucose deprivation and regulates microglia-induced hippocampal neuronal apoptosis via the miR-29b/SOCS-1-JAK2/STAT3-IL-1β axis [Huang et al. DOI:10.3390/cells11091381]. In a separate review, the circPTK2 was similarly noted to be induced after stroke, where it suppresses miR-29b, leading to JAK2/STAT3 activation, IL-1β production, and neuronal apoptosis [Mehta et al. DOI:10.1016/j.pneurobio.2020.101746].