Basic Information

Symbol
circPTK2
RNA Class
circRNA
Alias
Protein Tyrosine Kinase 2 PPP1R71 FAK1 FAK FADK Protein Phosphatase 1 Regulatory Subunit 71 Focal Adhesion Kinase-Related Nonkinase PTK2 Protein Tyrosine Kinase 2 Focal Adhesion Kinase 1 EC 2.7.10.2 Pp125FAK P125FAK FADK 1 FRNK Protein Phosphatase 1, Regulatory Subunit 71 FAK-Related Non-Kinase Polypeptide Protein-Tyrosine Kinase 2 EC 2.7.10
Location (GRCh37)
8:141668481-142005154 UCSC Genome Browser
Location (GRCh38)
8:140658382-140995055
UCSC Genome Browser Search in Marker Scope
Host gene
PTK2
Host category
mRNA
Forensic tag(s)
Sudden death from CNS diseases
External database
circbank

Transcripts

ID Type Location (GRCh37) Location (GRCh38) Length GC content
hsa_chr8_0163300 Intergenic-Intergenic chr8:141843958-141844804 chr8:140833859-140834705 847 nt 0.4227
hsa_chr8_0163400 Intergenic-Intergenic chr8:141845877-141846038 chr8:140835778-140835939 162 nt 0.4753
hsa_PTK2_0041600 Intron-Intron chr8:141848736-141850383 chr8:140838637-140840284 1648 nt 0.4302
hsa_PTK2_0041700 Intron-Exon-Intron chr8:141850964-141874498 chr8:140840865-140864399 94 nt 0.3085
hsa_PTK2_0041800 Intron-Exon-Intron chr8:141850964-141900868 chr8:140840865-140890769 227 nt 0.4405
hsa_PTK2_0042000 Intron-Exon-Intron chr8:141854046-141856421 chr8:140843947-140846322 63 nt 0.4286
hsa_PTK2_0042100 Intron-Exon-Intron chr8:141854046-141856777 chr8:140843947-140846678 154 nt 0.4091
hsa_PTK2_0042200 Intron-Exon-Intron chr8:141854046-141874498 chr8:140843947-140864399 305 nt 0.3836
hsa_PTK2_0042300 Intron-Exon-Intron chr8:141854046-141889736 chr8:140843947-140879637 241 nt 0.4979
hsa_PTK2_0042400 Intron-Exon-Intron chr8:141854046-141900868 chr8:140843947-140890769 301 nt 0.4352
Showing 451 to 460 of 573 entries
Forensic Context

A study in mice demonstrated that the circPTK2 is induced after oxygen-glucose deprivation and regulates microglia-induced hippocampal neuronal apoptosis via the miR-29b/SOCS-1-JAK2/STAT3-IL-1β axis [Huang et al. DOI:10.3390/cells11091381]. In a separate review, the circPTK2 was similarly noted to be induced after stroke, where it suppresses miR-29b, leading to JAK2/STAT3 activation, IL-1β production, and neuronal apoptosis [Mehta et al. DOI:10.1016/j.pneurobio.2020.101746].