Basic Information

Symbol
circPTK2
RNA Class
circRNA
Alias
Protein Tyrosine Kinase 2 PPP1R71 FAK1 FAK FADK Protein Phosphatase 1 Regulatory Subunit 71 Focal Adhesion Kinase-Related Nonkinase PTK2 Protein Tyrosine Kinase 2 Focal Adhesion Kinase 1 EC 2.7.10.2 Pp125FAK P125FAK FADK 1 FRNK Protein Phosphatase 1, Regulatory Subunit 71 FAK-Related Non-Kinase Polypeptide Protein-Tyrosine Kinase 2 EC 2.7.10
Location (GRCh37)
8:141668481-142005154 UCSC Genome Browser
Location (GRCh38)
8:140658382-140995055
UCSC Genome Browser Search in Marker Scope
Host gene
PTK2
Host category
mRNA
Forensic tag(s)
Sudden death from CNS diseases
External database
circbank

Transcripts

ID Type Location (GRCh37) Location (GRCh38) Length GC content
hsa_PTK2_0041900 Intron-Exon-Intron chr8:141854046-141935848 chr8:140843947-140925749 250 nt 0.3640
hsa_PTK2_0043000 Intron-Exon-Intron chr8:141856359-141857399 chr8:140846260-140847300 765 nt 0.3268
hsa_PTK2_0043300 Intron-Exon-Intron chr8:141856359-141884629 chr8:140846260-140874530 236 nt 0.3432
hsa_PTK2_0043100 Exon-Exon chr8:141856359-141900696 chr8:140846260-140890597 453 nt 0.4503
hsa_PTK2_0043400 Exon-Exon chr8:141856359-141900702 chr8:140846260-140890603 63 nt 0.4286
hsa_PTK2_0043200 Exon-Exon chr8:141856359-141900858 chr8:140846260-140890759 615 nt 0.4423
hsa_PTK2_0043500 Intron-Exon-Intron chr8:141856359-141903402 chr8:140846260-140893303 63 nt 0.4286
hsa_PTK2_0043600 Intron-Exon-Intron chr8:141856359-141919720 chr8:140846260-140909621 149 nt 0.4161
hsa_PTK2_0043700 Intron-Exon-Intron chr8:141856359-141922340 chr8:140846260-140912241 143 nt 0.4126
hsa_PTK2_0043800 Intron-Exon-Intron chr8:141856359-141922566 chr8:140846260-140912467 63 nt 0.4286
Showing 461 to 470 of 573 entries
Forensic Context

A study in mice demonstrated that the circPTK2 is induced after oxygen-glucose deprivation and regulates microglia-induced hippocampal neuronal apoptosis via the miR-29b/SOCS-1-JAK2/STAT3-IL-1β axis [Huang et al. DOI:10.3390/cells11091381]. In a separate review, the circPTK2 was similarly noted to be induced after stroke, where it suppresses miR-29b, leading to JAK2/STAT3 activation, IL-1β production, and neuronal apoptosis [Mehta et al. DOI:10.1016/j.pneurobio.2020.101746].