Basic Information

Symbol
circPTK2
RNA Class
circRNA
Alias
Protein Tyrosine Kinase 2 PPP1R71 FAK1 FAK FADK Protein Phosphatase 1 Regulatory Subunit 71 Focal Adhesion Kinase-Related Nonkinase PTK2 Protein Tyrosine Kinase 2 Focal Adhesion Kinase 1 EC 2.7.10.2 Pp125FAK P125FAK FADK 1 FRNK Protein Phosphatase 1, Regulatory Subunit 71 FAK-Related Non-Kinase Polypeptide Protein-Tyrosine Kinase 2 EC 2.7.10
Location (GRCh37)
8:141668481-142005154 UCSC Genome Browser
Location (GRCh38)
8:140658382-140995055
UCSC Genome Browser Search in Marker Scope
Host gene
PTK2
Host category
mRNA
Forensic tag(s)
Sudden death from CNS diseases
External database
circbank

Transcripts

ID Type Location (GRCh37) Location (GRCh38) Length GC content
hsa_PTK2_0043900 Exon-Exon chr8:141856359-141931022 chr8:140846260-140920923 63 nt 0.4286
hsa_PTK2_0044100 Intron-Exon-Intron chr8:141856359-141958822 chr8:140846260-140948723 69 nt 0.4203
hsa_PTK2_0044200 Intron-Exon-Intron chr8:141856359-141964946 chr8:140846260-140954847 58 nt 0.5000
hsa_PTK2_0044300 Intron-Exon-Intron chr8:141856359-141993741 chr8:140846260-140983642 69 nt 0.4348
hsa_PTK2_0044600 Exon-Exon chr8:141856698-141874498 chr8:140846599-140864399 80 nt 0.4000
hsa_PTK2_0044500 Exon-Exon chr8:141856698-141900702 chr8:140846599-140890603 396 nt 0.4520
hsa_PTK2_0044800 Exon-Exon chr8:141856698-141931231 chr8:140846599-140921132 319 nt 0.4577
hsa_PTK2_0044900 Exon-Exon chr8:141856698-141935848 chr8:140846599-140925749 80 nt 0.4000
hsa_PTK2_0045000 Intron-Exon-Intron chr8:141861833-141874498 chr8:140851734-140864399 250 nt 0.3560
hsa_PTK2_0045100 Intron-Exon-Intron chr8:141861833-141900868 chr8:140851734-140890769 250 nt 0.4040
Showing 471 to 480 of 573 entries
Forensic Context

A study in mice demonstrated that the circPTK2 is induced after oxygen-glucose deprivation and regulates microglia-induced hippocampal neuronal apoptosis via the miR-29b/SOCS-1-JAK2/STAT3-IL-1β axis [Huang et al. DOI:10.3390/cells11091381]. In a separate review, the circPTK2 was similarly noted to be induced after stroke, where it suppresses miR-29b, leading to JAK2/STAT3 activation, IL-1β production, and neuronal apoptosis [Mehta et al. DOI:10.1016/j.pneurobio.2020.101746].