Basic Information

Symbol
circPTK2
RNA Class
circRNA
Alias
Protein Tyrosine Kinase 2 PPP1R71 FAK1 FAK FADK Protein Phosphatase 1 Regulatory Subunit 71 Focal Adhesion Kinase-Related Nonkinase PTK2 Protein Tyrosine Kinase 2 Focal Adhesion Kinase 1 EC 2.7.10.2 Pp125FAK P125FAK FADK 1 FRNK Protein Phosphatase 1, Regulatory Subunit 71 FAK-Related Non-Kinase Polypeptide Protein-Tyrosine Kinase 2 EC 2.7.10
Location (GRCh37)
8:141668481-142005154 UCSC Genome Browser
Location (GRCh38)
8:140658382-140995055
UCSC Genome Browser Search in Marker Scope
Host gene
PTK2
Host category
mRNA
Forensic tag(s)
Sudden death from CNS diseases
External database
circbank

Transcripts

ID Type Location (GRCh37) Location (GRCh38) Length GC content
hsa_PTK2_0045200 Intron-Intron chr8:141862253-141862504 chr8:140852154-140852405 252 nt 0.3968
hsa_PTK2_0045300 Intron-Exon-Intron chr8:141871323-141874498 chr8:140861224-140864399 88 nt 0.3068
hsa_PTK2_0045400 Intron-Exon-Intron chr8:141871323-141900868 chr8:140861224-140890769 606 nt 0.4670
hsa_PTK2_0045500 Intron-Exon-Intron chr8:141871323-141935848 chr8:140861224-140925749 301 nt 0.4651
hsa_PTK2_0045600 Intron-Exon-Intron chr8:141872149-141900868 chr8:140862050-140890769 2744 nt 0.3823
hsa_PTK2_0045700 Intron-Exon-Intron chr8:141872384-141874498 chr8:140862285-140864399 2115 nt 0.3693
hsa_PTK2_0046500 Intron-Exon-Intron chr8:141874411-141884629 chr8:140864312-140874530 68 nt 0.3235
hsa_PTK2_0046100 Exon-Exon chr8:141874411-141900666 chr8:140864312-140890567 280 nt 0.4607
hsa_PTK2_0046600 Exon-Exon chr8:141874411-141900702 chr8:140864312-140890603 88 nt 0.3068
hsa_PTK2_0046700 Exon-Exon chr8:141874411-141900867 chr8:140864312-140890768 88 nt 0.3068
Showing 481 to 490 of 573 entries
Forensic Context

A study in mice demonstrated that the circPTK2 is induced after oxygen-glucose deprivation and regulates microglia-induced hippocampal neuronal apoptosis via the miR-29b/SOCS-1-JAK2/STAT3-IL-1β axis [Huang et al. DOI:10.3390/cells11091381]. In a separate review, the circPTK2 was similarly noted to be induced after stroke, where it suppresses miR-29b, leading to JAK2/STAT3 activation, IL-1β production, and neuronal apoptosis [Mehta et al. DOI:10.1016/j.pneurobio.2020.101746].