Basic Information

Symbol
circPTK2
RNA Class
circRNA
Alias
Protein Tyrosine Kinase 2 PPP1R71 FAK1 FAK FADK Protein Phosphatase 1 Regulatory Subunit 71 Focal Adhesion Kinase-Related Nonkinase PTK2 Protein Tyrosine Kinase 2 Focal Adhesion Kinase 1 EC 2.7.10.2 Pp125FAK P125FAK FADK 1 FRNK Protein Phosphatase 1, Regulatory Subunit 71 FAK-Related Non-Kinase Polypeptide Protein-Tyrosine Kinase 2 EC 2.7.10
Location (GRCh37)
8:141668481-142005154 UCSC Genome Browser
Location (GRCh38)
8:140658382-140995055
UCSC Genome Browser Search in Marker Scope
Host gene
PTK2
Host category
mRNA
Forensic tag(s)
Sudden death from CNS diseases
External database
circbank

Transcripts

ID Type Location (GRCh37) Location (GRCh38) Length GC content
hsa_PTK2_0046200 Intron-Exon-Intron chr8:141874411-141903402 chr8:140864312-140893303 250 nt 0.3560
hsa_PTK2_0046800 Intron-Exon-Intron chr8:141874411-141920090 chr8:140864312-140909991 88 nt 0.3068
hsa_PTK2_0046900 Intron-Exon-Intron chr8:141874411-141922340 chr8:140864312-140912241 88 nt 0.3068
hsa_PTK2_0047000 Intron-Exon-Intron chr8:141874411-141922566 chr8:140864312-140912467 94 nt 0.2979
hsa_PTK2_0047100 Exon-Exon chr8:141874411-141931231 chr8:140864312-140921132 88 nt 0.3068
hsa_PTK2_0047200 Exon-Exon chr8:141874411-141935844 chr8:140864312-140925745 567 nt 0.4568
hsa_PTK2_0047400 Intron-Exon-Intron chr8:141874411-141941162 chr8:140864312-140931063 315 nt 0.4032
hsa_PTK2_0047500 Intron-Exon-Intron chr8:141874411-141946663 chr8:140864312-140936564 88 nt 0.3068
hsa_PTK2_0046300 Intron-Exon-Intron chr8:141874411-141953625 chr8:140864312-140943526 250 nt 0.2800
hsa_PTK2_0046400 Intron-Exon-Intron chr8:141874411-141958822 chr8:140864312-140948723 250 nt 0.2920
Showing 491 to 500 of 573 entries
Forensic Context

A study in mice demonstrated that the circPTK2 is induced after oxygen-glucose deprivation and regulates microglia-induced hippocampal neuronal apoptosis via the miR-29b/SOCS-1-JAK2/STAT3-IL-1β axis [Huang et al. DOI:10.3390/cells11091381]. In a separate review, the circPTK2 was similarly noted to be induced after stroke, where it suppresses miR-29b, leading to JAK2/STAT3 activation, IL-1β production, and neuronal apoptosis [Mehta et al. DOI:10.1016/j.pneurobio.2020.101746].