Basic Information

Symbol
circPTK2
RNA Class
circRNA
Alias
Protein Tyrosine Kinase 2 PPP1R71 FAK1 FAK FADK Protein Phosphatase 1 Regulatory Subunit 71 Focal Adhesion Kinase-Related Nonkinase PTK2 Protein Tyrosine Kinase 2 Focal Adhesion Kinase 1 EC 2.7.10.2 Pp125FAK P125FAK FADK 1 FRNK Protein Phosphatase 1, Regulatory Subunit 71 FAK-Related Non-Kinase Polypeptide Protein-Tyrosine Kinase 2 EC 2.7.10
Location (GRCh37)
8:141668481-142005154 UCSC Genome Browser
Location (GRCh38)
8:140658382-140995055
UCSC Genome Browser Search in Marker Scope
Host gene
PTK2
Host category
mRNA
Forensic tag(s)
Sudden death from CNS diseases
External database
circbank

Transcripts

ID Type Location (GRCh37) Location (GRCh38) Length GC content
hsa_PTK2_0047600 Intron-Exon-Intron chr8:141874411-141964946 chr8:140864312-140954847 88 nt 0.3068
hsa_chr8_0163500 Intergenic-Intergenic chr8:141876807-141877099 chr8:140866708-140867000 293 nt 0.3447
hsa_PTK2_0047700 Intron-Intron chr8:141879241-141879774 chr8:140869142-140869675 534 nt 0.3783
hsa_PTK2_0047900 Intron-Exon-Intron chr8:141880585-141889736 chr8:140870486-140879637 250 nt 0.3400
hsa_PTK2_0048000 Intron-Exon-Intron chr8:141880618-141900868 chr8:140870519-140890769 250 nt 0.3440
hsa_PTK2_0048200 Intron-Exon-Intron chr8:141884562-141889736 chr8:140874463-140879637 167 nt 0.5329
hsa_chr8_0163600 Intergenic-Intergenic chr8:141885256-141885612 chr8:140875157-140875513 357 nt 0.3922
hsa_PTK2_0048300 Intron-Intron chr8:141887526-141888374 chr8:140877427-140878275 849 nt 0.3557
hsa_PTK2_0048600 Exon-Exon chr8:141889570-141900867 chr8:140879471-140890768 393 nt 0.4809
hsa_PTK2_0048700 Exon-Intron chr8:141889570-141919720 chr8:140879471-140909621 250 nt 0.3880
Showing 501 to 510 of 573 entries
Forensic Context

A study in mice demonstrated that the circPTK2 is induced after oxygen-glucose deprivation and regulates microglia-induced hippocampal neuronal apoptosis via the miR-29b/SOCS-1-JAK2/STAT3-IL-1β axis [Huang et al. DOI:10.3390/cells11091381]. In a separate review, the circPTK2 was similarly noted to be induced after stroke, where it suppresses miR-29b, leading to JAK2/STAT3 activation, IL-1β production, and neuronal apoptosis [Mehta et al. DOI:10.1016/j.pneurobio.2020.101746].