Basic Information

Symbol
circPTK2
RNA Class
circRNA
Alias
Protein Tyrosine Kinase 2 PPP1R71 FAK1 FAK FADK Protein Phosphatase 1 Regulatory Subunit 71 Focal Adhesion Kinase-Related Nonkinase PTK2 Protein Tyrosine Kinase 2 Focal Adhesion Kinase 1 EC 2.7.10.2 Pp125FAK P125FAK FADK 1 FRNK Protein Phosphatase 1, Regulatory Subunit 71 FAK-Related Non-Kinase Polypeptide Protein-Tyrosine Kinase 2 EC 2.7.10
Location (GRCh37)
8:141668481-142005154 UCSC Genome Browser
Location (GRCh38)
8:140658382-140995055
UCSC Genome Browser Search in Marker Scope
Host gene
PTK2
Host category
mRNA
Forensic tag(s)
Sudden death from CNS diseases
External database
circbank

Transcripts

ID Type Location (GRCh37) Location (GRCh38) Length GC content
hsa_PTK2_0049100 Exon-Intron chr8:141889570-141920090 chr8:140879471-140909991 167 nt 0.5329
hsa_PTK2_0049200 Exon-Intron chr8:141889570-141922566 chr8:140879471-140912467 114 nt 0.5351
hsa_PTK2_0048800 Exon-Exon chr8:141889570-141931231 chr8:140879471-140921132 713 nt 0.4698
hsa_PTK2_0049400 Exon-Intron chr8:141889570-141936531 chr8:140879471-140926432 45 nt 0.4889
hsa_PTK2_0048900 Exon-Intron chr8:141889570-141941162 chr8:140879471-140931063 250 nt 0.4600
hsa_PTK2_0049500 Exon-Intron chr8:141889570-141946663 chr8:140879471-140936564 61 nt 0.5082
hsa_PTK2_0049000 Exon-Intron chr8:141889570-141958822 chr8:140879471-140948723 250 nt 0.3880
hsa_PTK2_0049600 Exon-Intron chr8:141889570-141993741 chr8:140879471-140983642 167 nt 0.5329
hsa_PTK2_0049700 Exon-Intron chr8:141889570-141994283 chr8:140879471-140984184 895 nt 0.4872
hsa_PTK2_0049800 Exon-Exon chr8:141889650-141900675 chr8:140879551-140890576 121 nt 0.4959
Showing 511 to 520 of 573 entries
Forensic Context

A study in mice demonstrated that the circPTK2 is induced after oxygen-glucose deprivation and regulates microglia-induced hippocampal neuronal apoptosis via the miR-29b/SOCS-1-JAK2/STAT3-IL-1β axis [Huang et al. DOI:10.3390/cells11091381]. In a separate review, the circPTK2 was similarly noted to be induced after stroke, where it suppresses miR-29b, leading to JAK2/STAT3 activation, IL-1β production, and neuronal apoptosis [Mehta et al. DOI:10.1016/j.pneurobio.2020.101746].