Basic Information

Symbol
circPTK2
RNA Class
circRNA
Alias
Protein Tyrosine Kinase 2 PPP1R71 FAK1 FAK FADK Protein Phosphatase 1 Regulatory Subunit 71 Focal Adhesion Kinase-Related Nonkinase PTK2 Protein Tyrosine Kinase 2 Focal Adhesion Kinase 1 EC 2.7.10.2 Pp125FAK P125FAK FADK 1 FRNK Protein Phosphatase 1, Regulatory Subunit 71 FAK-Related Non-Kinase Polypeptide Protein-Tyrosine Kinase 2 EC 2.7.10
Location (GRCh37)
8:141668481-142005154 UCSC Genome Browser
Location (GRCh38)
8:140658382-140995055
UCSC Genome Browser Search in Marker Scope
Host gene
PTK2
Host category
mRNA
Forensic tag(s)
Sudden death from CNS diseases
External database
circbank

Transcripts

ID Type Location (GRCh37) Location (GRCh38) Length GC content
hsa_PTK2_0049900 Intron-Intron chr8:141890625-141890977 chr8:140880526-140880878 353 nt 0.3484
hsa_PTK2_0050000 Intron-Intron chr8:141891370-141891606 chr8:140881271-140881507 237 nt 0.4810
hsa_PTK2_0050200 Intron-Intron chr8:141893201-141894472 chr8:140883102-140884373 1272 nt 0.3954
hsa_PTK2_0050100 Intron-Exon-Intron chr8:141893201-141900868 chr8:140883102-140890769 250 nt 0.3160
hsa_PTK2_0050300 Intron-Intron chr8:141893898-141894138 chr8:140883799-140884039 241 nt 0.4274
hsa_PTK2_0050400 Intron-Intron chr8:141899917-141900084 chr8:140889818-140889985 168 nt 0.4167
hsa_PTK2_0050800 Exon-Exon chr8:141900642-141919720 chr8:140890543-140909621 227 nt 0.4405
hsa_PTK2_0050900 Exon-Intron chr8:141900642-141920090 chr8:140890543-140909991 98 nt 0.2857
hsa_PTK2_0051000 Exon-Intron chr8:141900642-141922340 chr8:140890543-140912241 351 nt 0.4644
hsa_PTK2_0050700 Exon-Exon chr8:141900642-141931231 chr8:140890543-140921132 546 nt 0.4505
Showing 521 to 530 of 573 entries
Forensic Context

A study in mice demonstrated that the circPTK2 is induced after oxygen-glucose deprivation and regulates microglia-induced hippocampal neuronal apoptosis via the miR-29b/SOCS-1-JAK2/STAT3-IL-1β axis [Huang et al. DOI:10.3390/cells11091381]. In a separate review, the circPTK2 was similarly noted to be induced after stroke, where it suppresses miR-29b, leading to JAK2/STAT3 activation, IL-1β production, and neuronal apoptosis [Mehta et al. DOI:10.1016/j.pneurobio.2020.101746].