Basic Information

Symbol
circPTK2
RNA Class
circRNA
Alias
Protein Tyrosine Kinase 2 PPP1R71 FAK1 FAK FADK Protein Phosphatase 1 Regulatory Subunit 71 Focal Adhesion Kinase-Related Nonkinase PTK2 Protein Tyrosine Kinase 2 Focal Adhesion Kinase 1 EC 2.7.10.2 Pp125FAK P125FAK FADK 1 FRNK Protein Phosphatase 1, Regulatory Subunit 71 FAK-Related Non-Kinase Polypeptide Protein-Tyrosine Kinase 2 EC 2.7.10
Location (GRCh37)
8:141668481-142005154 UCSC Genome Browser
Location (GRCh38)
8:140658382-140995055
UCSC Genome Browser Search in Marker Scope
Host gene
PTK2
Host category
mRNA
Forensic tag(s)
Sudden death from CNS diseases
External database
circbank

Transcripts

ID Type Location (GRCh37) Location (GRCh38) Length GC content
hsa_PTK2_0051100 Exon-Exon chr8:141900642-141935848 chr8:140890543-140925749 316 nt 0.4620
hsa_PTK2_0050600 Exon-Exon chr8:141900642-141958822 chr8:140890543-140948723 285 nt 0.4526
hsa_PTK2_0051200 Intron-Exon-Intron chr8:141900642-141964946 chr8:140890543-140954847 651 nt 0.4316
hsa_chr8_0163700 Intergenic-Intergenic chr8:141911135-141913528 chr8:140901036-140903429 2394 nt 0.4064
hsa_PTK2_0051300 Intron-Exon-Intron chr8:141919993-141937513 chr8:140909894-140927414 250 nt 0.2800
hsa_PTK2_0051400 Intron-Intron chr8:141921129-141922216 chr8:140911030-140912117 1088 nt 0.3447
hsa_PTK2_0051500 Intron-Exon chr8:141922217-141931231 chr8:140912118-140921132 250 nt 0.3720
hsa_PTK2_0051600 Intron-Intron chr8:141929314-141929491 chr8:140919215-140919392 178 nt 0.3652
hsa_PTK2_0051700 Intron-Exon-Intron chr8:141930913-141935848 chr8:140920814-140925749 507 nt 0.4497
hsa_PTK2_0051800 Intron-Intron chr8:141933137-141934332 chr8:140923038-140924233 1196 nt 0.4206
Showing 531 to 540 of 573 entries
Forensic Context

A study in mice demonstrated that the circPTK2 is induced after oxygen-glucose deprivation and regulates microglia-induced hippocampal neuronal apoptosis via the miR-29b/SOCS-1-JAK2/STAT3-IL-1β axis [Huang et al. DOI:10.3390/cells11091381]. In a separate review, the circPTK2 was similarly noted to be induced after stroke, where it suppresses miR-29b, leading to JAK2/STAT3 activation, IL-1β production, and neuronal apoptosis [Mehta et al. DOI:10.1016/j.pneurobio.2020.101746].