Basic Information

Symbol
circPTK2
RNA Class
circRNA
Alias
Protein Tyrosine Kinase 2 PPP1R71 FAK1 FAK FADK Protein Phosphatase 1 Regulatory Subunit 71 Focal Adhesion Kinase-Related Nonkinase PTK2 Protein Tyrosine Kinase 2 Focal Adhesion Kinase 1 EC 2.7.10.2 Pp125FAK P125FAK FADK 1 FRNK Protein Phosphatase 1, Regulatory Subunit 71 FAK-Related Non-Kinase Polypeptide Protein-Tyrosine Kinase 2 EC 2.7.10
Location (GRCh37)
8:141668481-142005154 UCSC Genome Browser
Location (GRCh38)
8:140658382-140995055
UCSC Genome Browser Search in Marker Scope
Host gene
PTK2
Host category
mRNA
Forensic tag(s)
Sudden death from CNS diseases
External database
circbank

Transcripts

ID Type Location (GRCh37) Location (GRCh38) Length GC content
hsa_PTK2_0051900 Intron-Intron chr8:141934024-141934449 chr8:140923925-140924350 426 nt 0.5070
hsa_PTK2_0052000 Intron-Intron chr8:141934462-141934610 chr8:140924363-140924511 149 nt 0.4430
hsa_PTK2_0052200 Exon-Intron chr8:141935760-141944153 chr8:140925661-140934054 250 nt 0.3240
hsa_PTK2_0052300 Exon-Intron chr8:141935760-141964946 chr8:140925661-140954847 250 nt 0.3360
hsa_PTK2_0052400 Intron-Intron chr8:141936085-141936486 chr8:140925986-140926387 402 nt 0.3831
hsa_PTK2_0052500 Intron-Intron chr8:141937977-141943060 chr8:140927878-140932961 250 nt 0.3320
hsa_PTK2_0052600 Intron-Intron chr8:141944467-141944775 chr8:140934368-140934676 309 nt 0.3916
hsa_chr8_0163800 Intergenic-Intergenic chr8:141948777-141948970 chr8:140938678-140938871 194 nt 0.3814
hsa_PTK2_0052700 Intron-Intron chr8:141953108-141953356 chr8:140943009-140943257 249 nt 0.4699
hsa_PTK2_0052800 Intron-Intron chr8:141953843-141954469 chr8:140943744-140944370 627 nt 0.3589
Showing 541 to 550 of 573 entries
Forensic Context

A study in mice demonstrated that the circPTK2 is induced after oxygen-glucose deprivation and regulates microglia-induced hippocampal neuronal apoptosis via the miR-29b/SOCS-1-JAK2/STAT3-IL-1β axis [Huang et al. DOI:10.3390/cells11091381]. In a separate review, the circPTK2 was similarly noted to be induced after stroke, where it suppresses miR-29b, leading to JAK2/STAT3 activation, IL-1β production, and neuronal apoptosis [Mehta et al. DOI:10.1016/j.pneurobio.2020.101746].